TY - JOUR
T1 - Insulin-like growth factor binding protein-5 in osteogenesis
T2 - Facilitator or inhibitor?
AU - Mukherjee, Aditi
AU - Rotwein, Peter
N1 - Funding Information:
This review was supported in part by US National Institutes of Health research Grants, RO1 DK63073 and RO1 DK42748 (to P. R.).
PY - 2007/6
Y1 - 2007/6
N2 - The insulin-like growth factors (IGFs) play a central role in controlling somatic growth in mammals and exert anabolic effects on most tissues, including bone. IGF action is mediated by the IGF-I receptor and additionally is regulated by six high-affinity IGF binding proteins (IGFBP-1 through IGFBP-6), of which IGFBP-4 and IGFBP-5 are most abundant in bone. The focus of this brief review is on the role of IGFBP-5 in bone biology. IGFBP-5 has been implicated as a pro-osteogenic factor in several studies but conversely has been shown to act as an inhibitor of bone formation, primarily by interfering with IGF actions on osteoblasts. These potentially contradictory effects of IGFBP-5 in bone are further complicated by observations indicating that IGFBP-5 additionally may function in an IGF-independent way, and may have been accentuated by differences in both experimental design and methodology among published studies. Suggestions are made for a more systematic approach to help discern the true roles of IGFBP-5 in bone physiology.
AB - The insulin-like growth factors (IGFs) play a central role in controlling somatic growth in mammals and exert anabolic effects on most tissues, including bone. IGF action is mediated by the IGF-I receptor and additionally is regulated by six high-affinity IGF binding proteins (IGFBP-1 through IGFBP-6), of which IGFBP-4 and IGFBP-5 are most abundant in bone. The focus of this brief review is on the role of IGFBP-5 in bone biology. IGFBP-5 has been implicated as a pro-osteogenic factor in several studies but conversely has been shown to act as an inhibitor of bone formation, primarily by interfering with IGF actions on osteoblasts. These potentially contradictory effects of IGFBP-5 in bone are further complicated by observations indicating that IGFBP-5 additionally may function in an IGF-independent way, and may have been accentuated by differences in both experimental design and methodology among published studies. Suggestions are made for a more systematic approach to help discern the true roles of IGFBP-5 in bone physiology.
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U2 - 10.1016/j.ghir.2007.01.005
DO - 10.1016/j.ghir.2007.01.005
M3 - Review article
C2 - 17317255
AN - SCOPUS:34250004672
SN - 1096-6374
VL - 17
SP - 179
EP - 185
JO - Growth Hormone and IGF Research
JF - Growth Hormone and IGF Research
IS - 3
ER -