Insulin in the brain increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity

Mollie P. Pricher, Korrina L. Freeman, Virginia Brooks

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Chronic central administration of insulin increases the gain of baroreflex control of heart rate, but whether baroreflex control of the sympathetic nervous system is similarly affected is unknown. The sites and mechanisms by which brain insulin influences the baroreflex are also unclear. Therefore, the present study tested the hypothesis that acute infusion of insulin into the brain ventricles of urethane-anesthetized rats increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity and that this action is gender specific. Furthermore, to identify the location within the brain that mediates these effects, insulin was infused into either the lateral ventricle or the fourth ventricle. Lateral ventricular insulin infusion increased the gain of baroreflex control of heart rate (2.1±0.3 to 4.0±0.6 bpm/mm Hg; P

Original languageEnglish (US)
Pages (from-to)514-520
Number of pages7
JournalHypertension
Volume51
Issue number2 PART 2
DOIs
StatePublished - Feb 2008

Fingerprint

Baroreflex
Heart Rate
Insulin
Brain
Fourth Ventricle
Lateral Ventricles
Urethane
Sympathetic Nervous System

Keywords

  • Male and female rats
  • Mean arterial pressure
  • Nitroprusside
  • Phenylephrine
  • Urethane anesthesia

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Insulin in the brain increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity. / Pricher, Mollie P.; Freeman, Korrina L.; Brooks, Virginia.

In: Hypertension, Vol. 51, No. 2 PART 2, 02.2008, p. 514-520.

Research output: Contribution to journalArticle

Pricher, Mollie P. ; Freeman, Korrina L. ; Brooks, Virginia. / Insulin in the brain increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity. In: Hypertension. 2008 ; Vol. 51, No. 2 PART 2. pp. 514-520.
@article{8ca259f531f44fb287875011f0214e27,
title = "Insulin in the brain increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity",
abstract = "Chronic central administration of insulin increases the gain of baroreflex control of heart rate, but whether baroreflex control of the sympathetic nervous system is similarly affected is unknown. The sites and mechanisms by which brain insulin influences the baroreflex are also unclear. Therefore, the present study tested the hypothesis that acute infusion of insulin into the brain ventricles of urethane-anesthetized rats increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity and that this action is gender specific. Furthermore, to identify the location within the brain that mediates these effects, insulin was infused into either the lateral ventricle or the fourth ventricle. Lateral ventricular insulin infusion increased the gain of baroreflex control of heart rate (2.1±0.3 to 4.0±0.6 bpm/mm Hg; P",
keywords = "Male and female rats, Mean arterial pressure, Nitroprusside, Phenylephrine, Urethane anesthesia",
author = "Pricher, {Mollie P.} and Freeman, {Korrina L.} and Virginia Brooks",
year = "2008",
month = "2",
doi = "10.1161/HYPERTENSIONAHA.107.102608",
language = "English (US)",
volume = "51",
pages = "514--520",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "2 PART 2",

}

TY - JOUR

T1 - Insulin in the brain increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity

AU - Pricher, Mollie P.

AU - Freeman, Korrina L.

AU - Brooks, Virginia

PY - 2008/2

Y1 - 2008/2

N2 - Chronic central administration of insulin increases the gain of baroreflex control of heart rate, but whether baroreflex control of the sympathetic nervous system is similarly affected is unknown. The sites and mechanisms by which brain insulin influences the baroreflex are also unclear. Therefore, the present study tested the hypothesis that acute infusion of insulin into the brain ventricles of urethane-anesthetized rats increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity and that this action is gender specific. Furthermore, to identify the location within the brain that mediates these effects, insulin was infused into either the lateral ventricle or the fourth ventricle. Lateral ventricular insulin infusion increased the gain of baroreflex control of heart rate (2.1±0.3 to 4.0±0.6 bpm/mm Hg; P

AB - Chronic central administration of insulin increases the gain of baroreflex control of heart rate, but whether baroreflex control of the sympathetic nervous system is similarly affected is unknown. The sites and mechanisms by which brain insulin influences the baroreflex are also unclear. Therefore, the present study tested the hypothesis that acute infusion of insulin into the brain ventricles of urethane-anesthetized rats increases gain of baroreflex control of heart rate and lumbar sympathetic nerve activity and that this action is gender specific. Furthermore, to identify the location within the brain that mediates these effects, insulin was infused into either the lateral ventricle or the fourth ventricle. Lateral ventricular insulin infusion increased the gain of baroreflex control of heart rate (2.1±0.3 to 4.0±0.6 bpm/mm Hg; P

KW - Male and female rats

KW - Mean arterial pressure

KW - Nitroprusside

KW - Phenylephrine

KW - Urethane anesthesia

UR - http://www.scopus.com/inward/record.url?scp=38549132891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38549132891&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.107.102608

DO - 10.1161/HYPERTENSIONAHA.107.102608

M3 - Article

VL - 51

SP - 514

EP - 520

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 2 PART 2

ER -