Insulin gene structure and function: A review of studies using recombinant DNA methodology

M. A. Permutt, J. Chirgwin, P. Rotwein, S. Giddings

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, and factors related to its normal functioning in the beta cells of the pancreas are explored. DNA polymorphisms near the insulin locus and their relationship with certain types of diabetes are considered, as are recently characterized human insulin gene mutations. Events in animal models for diabetes that reflect altered insulin gene expression are discussed and the potential application of gene therapy in human diabetes is examined. Recombinant DNA methodology holds great promise as a tool for providing better understanding of the causes of diabetes and potential curative treatment.

Original languageEnglish (US)
Pages (from-to)386-394
Number of pages9
JournalDiabetes Care
Volume7
Issue number4
StatePublished - 1984
Externally publishedYes

Fingerprint

Recombinant DNA
Insulin
Genes
Genetic Therapy
Molecular Biology
Pancreas
Diabetes Mellitus
Animal Models
Gene Expression
Mutation
DNA

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Permutt, M. A., Chirgwin, J., Rotwein, P., & Giddings, S. (1984). Insulin gene structure and function: A review of studies using recombinant DNA methodology. Diabetes Care, 7(4), 386-394.

Insulin gene structure and function : A review of studies using recombinant DNA methodology. / Permutt, M. A.; Chirgwin, J.; Rotwein, P.; Giddings, S.

In: Diabetes Care, Vol. 7, No. 4, 1984, p. 386-394.

Research output: Contribution to journalArticle

Permutt, MA, Chirgwin, J, Rotwein, P & Giddings, S 1984, 'Insulin gene structure and function: A review of studies using recombinant DNA methodology', Diabetes Care, vol. 7, no. 4, pp. 386-394.
Permutt MA, Chirgwin J, Rotwein P, Giddings S. Insulin gene structure and function: A review of studies using recombinant DNA methodology. Diabetes Care. 1984;7(4):386-394.
Permutt, M. A. ; Chirgwin, J. ; Rotwein, P. ; Giddings, S. / Insulin gene structure and function : A review of studies using recombinant DNA methodology. In: Diabetes Care. 1984 ; Vol. 7, No. 4. pp. 386-394.
@article{8f49353bc1c247c3a2198bdafa1b52a4,
title = "Insulin gene structure and function: A review of studies using recombinant DNA methodology",
abstract = "This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, and factors related to its normal functioning in the beta cells of the pancreas are explored. DNA polymorphisms near the insulin locus and their relationship with certain types of diabetes are considered, as are recently characterized human insulin gene mutations. Events in animal models for diabetes that reflect altered insulin gene expression are discussed and the potential application of gene therapy in human diabetes is examined. Recombinant DNA methodology holds great promise as a tool for providing better understanding of the causes of diabetes and potential curative treatment.",
author = "Permutt, {M. A.} and J. Chirgwin and P. Rotwein and S. Giddings",
year = "1984",
language = "English (US)",
volume = "7",
pages = "386--394",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "4",

}

TY - JOUR

T1 - Insulin gene structure and function

T2 - A review of studies using recombinant DNA methodology

AU - Permutt, M. A.

AU - Chirgwin, J.

AU - Rotwein, P.

AU - Giddings, S.

PY - 1984

Y1 - 1984

N2 - This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, and factors related to its normal functioning in the beta cells of the pancreas are explored. DNA polymorphisms near the insulin locus and their relationship with certain types of diabetes are considered, as are recently characterized human insulin gene mutations. Events in animal models for diabetes that reflect altered insulin gene expression are discussed and the potential application of gene therapy in human diabetes is examined. Recombinant DNA methodology holds great promise as a tool for providing better understanding of the causes of diabetes and potential curative treatment.

AB - This review focuses on recent advances in molecular biology as they pertain to the insulin gene and diabetes mellitus. The structure of the human insulin gene is examined, and factors related to its normal functioning in the beta cells of the pancreas are explored. DNA polymorphisms near the insulin locus and their relationship with certain types of diabetes are considered, as are recently characterized human insulin gene mutations. Events in animal models for diabetes that reflect altered insulin gene expression are discussed and the potential application of gene therapy in human diabetes is examined. Recombinant DNA methodology holds great promise as a tool for providing better understanding of the causes of diabetes and potential curative treatment.

UR - http://www.scopus.com/inward/record.url?scp=0021217714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021217714&partnerID=8YFLogxK

M3 - Article

C2 - 6381010

AN - SCOPUS:0021217714

VL - 7

SP - 386

EP - 394

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 4

ER -