Insulin-dependent diabetic microangiopathy in the inner ear

Timothy Smith, Eileen Raynor, Jiri Prazma, John E. Buenting, Harold C. Pillsbury

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Thickening of the basement membrane in capillaries is implicated in the microangiopathic complications of diabetes mellitus. This study was designed to evaluate microangiopathic changes of the inner ear associated with insulin-dependent diabetes mellitus (IDDM) and concurrent moderate-intensity noise exposure. Male Sprague-Dawley rats were injected with streptozotocin (65 mg/kg) to induce IDDM. Half of the control and diabetic animals were exposed to chronic noise of 95 dB over the 6-month study period. Photomicrographs of the capillaries in the stria vascularis were obtained by transmission electron microscopy, and basement-membrane thickness was measured with an image processing system. This study quantitatively demonstrates basement-membrane thickening consistent with diabetic microangiopathy in the inner ear of IDDM rats. Noise exposure did not significantly change basement-membrane thickness in either diabetic or control animals.

Original languageEnglish (US)
Pages (from-to)236-240
Number of pages5
JournalLaryngoscope
Volume105
Issue number3
StatePublished - 1995
Externally publishedYes

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Diabetic Angiopathies
Inner Ear
Basement Membrane
Type 1 Diabetes Mellitus
Insulin
Noise
Stria Vascularis
Diabetes Complications
Streptozocin
Transmission Electron Microscopy
Sprague Dawley Rats

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Smith, T., Raynor, E., Prazma, J., Buenting, J. E., & Pillsbury, H. C. (1995). Insulin-dependent diabetic microangiopathy in the inner ear. Laryngoscope, 105(3), 236-240.

Insulin-dependent diabetic microangiopathy in the inner ear. / Smith, Timothy; Raynor, Eileen; Prazma, Jiri; Buenting, John E.; Pillsbury, Harold C.

In: Laryngoscope, Vol. 105, No. 3, 1995, p. 236-240.

Research output: Contribution to journalArticle

Smith, T, Raynor, E, Prazma, J, Buenting, JE & Pillsbury, HC 1995, 'Insulin-dependent diabetic microangiopathy in the inner ear', Laryngoscope, vol. 105, no. 3, pp. 236-240.
Smith T, Raynor E, Prazma J, Buenting JE, Pillsbury HC. Insulin-dependent diabetic microangiopathy in the inner ear. Laryngoscope. 1995;105(3):236-240.
Smith, Timothy ; Raynor, Eileen ; Prazma, Jiri ; Buenting, John E. ; Pillsbury, Harold C. / Insulin-dependent diabetic microangiopathy in the inner ear. In: Laryngoscope. 1995 ; Vol. 105, No. 3. pp. 236-240.
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