Insulin and insulin-like growth factors in the CNS

Denis G. Baskin, Barbara J. Wilcox, Dianne P. Figlewicz, Daniel Dorsa

Research output: Contribution to journalArticle

272 Citations (Scopus)

Abstract

Insulin has long been recognized as a major endocrine regulator of the uptake, cellular transport, and intermediary metabolism of small nutrient molecules such as amino acids, fatty acids, and glucose1. Adipose tissue and skeletal muscle are the classical major target of insulin action; the CNS, in contrast, has traditionally been considered to be largely insulin-insensitive. However, clues that insulin may have physiological functions in the CNS began to emerge in the 1960s, and an impressive body of literature has since accumulated about insulin in the CNS. Although insulin now regularly appears in litanies cataloging CNS peptides, its status as a CNS regulatory peptide remains obscure and elusive. The situation has become more clouded with the recent discovery that insulin-like growth-factors (IGFs) and their receptors are also present in the CNS. Since IGFs and insulin share similar primary amino acid structure, receptor binding, and biological activity2, any discussion about insulin as a CNS regulatory peptide must also consider the IGFs. In the present article, we summarize the status of insulin and IGFs as regulatory peptides in the CNS. Our choice of literature has been selective, with a focus on recent reports, controversial issues, and unsolved problems. Readers are referred to previous reviews for much of the earlier literature1-5.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalTrends in Neurosciences
Volume11
Issue number3
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Somatomedins
Insulin
Peptides
Cataloging
Amino Acid Receptors
Somatomedin Receptors
Adipose Tissue
Skeletal Muscle
Fatty Acids
Amino Acids
Food

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Insulin and insulin-like growth factors in the CNS. / Baskin, Denis G.; Wilcox, Barbara J.; Figlewicz, Dianne P.; Dorsa, Daniel.

In: Trends in Neurosciences, Vol. 11, No. 3, 1988, p. 107-111.

Research output: Contribution to journalArticle

Baskin, Denis G. ; Wilcox, Barbara J. ; Figlewicz, Dianne P. ; Dorsa, Daniel. / Insulin and insulin-like growth factors in the CNS. In: Trends in Neurosciences. 1988 ; Vol. 11, No. 3. pp. 107-111.
@article{25567612d31841818513141dc3d438c8,
title = "Insulin and insulin-like growth factors in the CNS",
abstract = "Insulin has long been recognized as a major endocrine regulator of the uptake, cellular transport, and intermediary metabolism of small nutrient molecules such as amino acids, fatty acids, and glucose1. Adipose tissue and skeletal muscle are the classical major target of insulin action; the CNS, in contrast, has traditionally been considered to be largely insulin-insensitive. However, clues that insulin may have physiological functions in the CNS began to emerge in the 1960s, and an impressive body of literature has since accumulated about insulin in the CNS. Although insulin now regularly appears in litanies cataloging CNS peptides, its status as a CNS regulatory peptide remains obscure and elusive. The situation has become more clouded with the recent discovery that insulin-like growth-factors (IGFs) and their receptors are also present in the CNS. Since IGFs and insulin share similar primary amino acid structure, receptor binding, and biological activity2, any discussion about insulin as a CNS regulatory peptide must also consider the IGFs. In the present article, we summarize the status of insulin and IGFs as regulatory peptides in the CNS. Our choice of literature has been selective, with a focus on recent reports, controversial issues, and unsolved problems. Readers are referred to previous reviews for much of the earlier literature1-5.",
author = "Baskin, {Denis G.} and Wilcox, {Barbara J.} and Figlewicz, {Dianne P.} and Daniel Dorsa",
year = "1988",
doi = "10.1016/0166-2236(88)90155-5",
language = "English (US)",
volume = "11",
pages = "107--111",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Insulin and insulin-like growth factors in the CNS

AU - Baskin, Denis G.

AU - Wilcox, Barbara J.

AU - Figlewicz, Dianne P.

AU - Dorsa, Daniel

PY - 1988

Y1 - 1988

N2 - Insulin has long been recognized as a major endocrine regulator of the uptake, cellular transport, and intermediary metabolism of small nutrient molecules such as amino acids, fatty acids, and glucose1. Adipose tissue and skeletal muscle are the classical major target of insulin action; the CNS, in contrast, has traditionally been considered to be largely insulin-insensitive. However, clues that insulin may have physiological functions in the CNS began to emerge in the 1960s, and an impressive body of literature has since accumulated about insulin in the CNS. Although insulin now regularly appears in litanies cataloging CNS peptides, its status as a CNS regulatory peptide remains obscure and elusive. The situation has become more clouded with the recent discovery that insulin-like growth-factors (IGFs) and their receptors are also present in the CNS. Since IGFs and insulin share similar primary amino acid structure, receptor binding, and biological activity2, any discussion about insulin as a CNS regulatory peptide must also consider the IGFs. In the present article, we summarize the status of insulin and IGFs as regulatory peptides in the CNS. Our choice of literature has been selective, with a focus on recent reports, controversial issues, and unsolved problems. Readers are referred to previous reviews for much of the earlier literature1-5.

AB - Insulin has long been recognized as a major endocrine regulator of the uptake, cellular transport, and intermediary metabolism of small nutrient molecules such as amino acids, fatty acids, and glucose1. Adipose tissue and skeletal muscle are the classical major target of insulin action; the CNS, in contrast, has traditionally been considered to be largely insulin-insensitive. However, clues that insulin may have physiological functions in the CNS began to emerge in the 1960s, and an impressive body of literature has since accumulated about insulin in the CNS. Although insulin now regularly appears in litanies cataloging CNS peptides, its status as a CNS regulatory peptide remains obscure and elusive. The situation has become more clouded with the recent discovery that insulin-like growth-factors (IGFs) and their receptors are also present in the CNS. Since IGFs and insulin share similar primary amino acid structure, receptor binding, and biological activity2, any discussion about insulin as a CNS regulatory peptide must also consider the IGFs. In the present article, we summarize the status of insulin and IGFs as regulatory peptides in the CNS. Our choice of literature has been selective, with a focus on recent reports, controversial issues, and unsolved problems. Readers are referred to previous reviews for much of the earlier literature1-5.

UR - http://www.scopus.com/inward/record.url?scp=0023865299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023865299&partnerID=8YFLogxK

U2 - 10.1016/0166-2236(88)90155-5

DO - 10.1016/0166-2236(88)90155-5

M3 - Article

VL - 11

SP - 107

EP - 111

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 3

ER -