@article{1eed98101b3640148bccd5c7589ad216,
title = "Insulin and ACTH production by a streptozotocin responsive islet cell carcinoma",
abstract = "We describe a patient with insulin and ACTH production by an islet cell carcinoma with hepatic metastases and cite three previously reported cases of this bihormonal production. The patient was treated with multiple instillations of streptozotocin, a drug with specific beta cell toxicity. After therapy, insulin and ACTH levels declined. These responses after the administration of a drug with beta cell specificity are evidence that both insulin and ACTH were produced by beta cells rather than by multiple cell types.",
author = "Walter, {Robert M.} and Ensinck, {John W.} and Howard Ricketts and Kendall, {John W.} and Williams, {Robert H.}",
note = "Funding Information: ROBERT M. WALTER, M.D. JOHN W. ENSINCK, M.D. HOWARD RICKETTS, M.D. Seattle, Washington JOHN W. KENDALL, M.D. Portland, Oregon ROBERT H. WILLIAMS, M.D. Seattle, Washington From the Departments of Medicine and Radiology, University of Washington School of Medicine, Seattle, Washington, and the Department of Medicine, University of Oregon School of Medicine, Portland, Oregon. This investigation was supported by U.S. Public Health Service Research Grant AM-13457, Program Project Grant PO-l -HDO-4872. and a research award from the American Diabetes Association. A portion of this work was conducted on the Clinical Research Center Facility of the University of Washington supported by the NIH (Grant RR-37). Requests for reprints should be addressed to Dr. John W. Ensinck, Department of Medicine, University of Washington, Seattle, Washington 98195. Manuscript accepted April 26, 1973.",
year = "1973",
month = nov,
doi = "10.1016/0002-9343(73)90189-7",
language = "English (US)",
volume = "55",
pages = "667--670",
journal = "The American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "5",
}