Instructing an embryonic stem cell-derived oocyte fate: Lessons from endogenous oogenesis

Cory R. Nicholas, Shawn L. Chavez, Valerie L. Baker, Renee A. Reijo Pera

    Research output: Contribution to journalReview article

    40 Scopus citations

    Abstract

    Female reproductive potential is limited in the majority of species due to oocyte depletion. Because functional human oocytes are restricted in number and accessibility, a robust system to differentiate oocytes from stem cells would enable a thorough investigation of the genetic, epigenetic, and environmental factors affecting human oocyte development. Also, the differentiation of functional oocytes from stem cells may permit the success of human somatic cell nuclear transfer for reprogramming studies and for the production of patient-specific embryonic stem cells (ESCs). Thus, ESC-derived oocytes could ultimately help to restore fertility in women. Here, we review endogenous and ESC-derived oocyte development, and we discuss the potential and challenges for differentiating functional oocytes from ESCs.

    Original languageEnglish (US)
    Pages (from-to)264-283
    Number of pages20
    JournalEndocrine reviews
    Volume30
    Issue number3
    DOIs
    StatePublished - May 1 2009

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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