Institutional review of the implementation and use of a Clostridium difficile infection bundle and probiotics in adult trauma patients

Aravind K. Bommiasamy, Christopher Connelly, Alexi Moren, Chris Dodgion, Kelsey Bestall, Anthony Cline, Robert Martindale, Martin Schreiber, Laszlo N. Kiraly

Research output: Contribution to journalArticle

Abstract

Background: Clostridium difficile infection (CDI) is a common cause of healthcare associated infections contributing to morbidity and mortality. Our objective was to evaluate the impact of the implementation of a CDI bundle along with probiotic utilization. Methods: A retrospective review of trauma admissions from 2008 to 2014 was performed. The CDI bundle was implemented in stages from 2009 through 2014 with probiotics initiated in 2010. The bundle included changes in cleaning practices, education, screening, and contact precautions. Results: 4632 (49%) patients received antibiotics with 21% receiving probiotics. Probiotic use was associated with increased age, male sex, more severely injured, and antibiotic use. CDI incidence decreased from 11.2 to 4.8 per 1000 admissions, p =.03. Among patients who received antibiotics CDI incidence decreased from 2.2% to 0.7%, p =.01. Conclusions: We report the largest series of a CDI bundle implementation including probiotics. During the period of adoption of these interventions, the incidence of CDI decreased significantly.

Original languageEnglish (US)
JournalAmerican Journal of Surgery
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Clostridium Infections
Clostridium difficile
Probiotics
Wounds and Injuries
Anti-Bacterial Agents
Incidence
Cross Infection
Morbidity
Education
Mortality

Keywords

  • Clostridium difficile
  • Infection
  • Probiotic
  • Trauma

ASJC Scopus subject areas

  • Surgery

Cite this

Institutional review of the implementation and use of a Clostridium difficile infection bundle and probiotics in adult trauma patients. / Bommiasamy, Aravind K.; Connelly, Christopher; Moren, Alexi; Dodgion, Chris; Bestall, Kelsey; Cline, Anthony; Martindale, Robert; Schreiber, Martin; Kiraly, Laszlo N.

In: American Journal of Surgery, 01.01.2018.

Research output: Contribution to journalArticle

Bommiasamy, Aravind K. ; Connelly, Christopher ; Moren, Alexi ; Dodgion, Chris ; Bestall, Kelsey ; Cline, Anthony ; Martindale, Robert ; Schreiber, Martin ; Kiraly, Laszlo N. / Institutional review of the implementation and use of a Clostridium difficile infection bundle and probiotics in adult trauma patients. In: American Journal of Surgery. 2018.
@article{e28fe5e39ab748d2a0674674d51e7f57,
title = "Institutional review of the implementation and use of a Clostridium difficile infection bundle and probiotics in adult trauma patients",
abstract = "Background: Clostridium difficile infection (CDI) is a common cause of healthcare associated infections contributing to morbidity and mortality. Our objective was to evaluate the impact of the implementation of a CDI bundle along with probiotic utilization. Methods: A retrospective review of trauma admissions from 2008 to 2014 was performed. The CDI bundle was implemented in stages from 2009 through 2014 with probiotics initiated in 2010. The bundle included changes in cleaning practices, education, screening, and contact precautions. Results: 4632 (49{\%}) patients received antibiotics with 21{\%} receiving probiotics. Probiotic use was associated with increased age, male sex, more severely injured, and antibiotic use. CDI incidence decreased from 11.2 to 4.8 per 1000 admissions, p =.03. Among patients who received antibiotics CDI incidence decreased from 2.2{\%} to 0.7{\%}, p =.01. Conclusions: We report the largest series of a CDI bundle implementation including probiotics. During the period of adoption of these interventions, the incidence of CDI decreased significantly.",
keywords = "Clostridium difficile, Infection, Probiotic, Trauma",
author = "Bommiasamy, {Aravind K.} and Christopher Connelly and Alexi Moren and Chris Dodgion and Kelsey Bestall and Anthony Cline and Robert Martindale and Martin Schreiber and Kiraly, {Laszlo N.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.amjsurg.2018.01.005",
language = "English (US)",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Institutional review of the implementation and use of a Clostridium difficile infection bundle and probiotics in adult trauma patients

AU - Bommiasamy, Aravind K.

AU - Connelly, Christopher

AU - Moren, Alexi

AU - Dodgion, Chris

AU - Bestall, Kelsey

AU - Cline, Anthony

AU - Martindale, Robert

AU - Schreiber, Martin

AU - Kiraly, Laszlo N.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Clostridium difficile infection (CDI) is a common cause of healthcare associated infections contributing to morbidity and mortality. Our objective was to evaluate the impact of the implementation of a CDI bundle along with probiotic utilization. Methods: A retrospective review of trauma admissions from 2008 to 2014 was performed. The CDI bundle was implemented in stages from 2009 through 2014 with probiotics initiated in 2010. The bundle included changes in cleaning practices, education, screening, and contact precautions. Results: 4632 (49%) patients received antibiotics with 21% receiving probiotics. Probiotic use was associated with increased age, male sex, more severely injured, and antibiotic use. CDI incidence decreased from 11.2 to 4.8 per 1000 admissions, p =.03. Among patients who received antibiotics CDI incidence decreased from 2.2% to 0.7%, p =.01. Conclusions: We report the largest series of a CDI bundle implementation including probiotics. During the period of adoption of these interventions, the incidence of CDI decreased significantly.

AB - Background: Clostridium difficile infection (CDI) is a common cause of healthcare associated infections contributing to morbidity and mortality. Our objective was to evaluate the impact of the implementation of a CDI bundle along with probiotic utilization. Methods: A retrospective review of trauma admissions from 2008 to 2014 was performed. The CDI bundle was implemented in stages from 2009 through 2014 with probiotics initiated in 2010. The bundle included changes in cleaning practices, education, screening, and contact precautions. Results: 4632 (49%) patients received antibiotics with 21% receiving probiotics. Probiotic use was associated with increased age, male sex, more severely injured, and antibiotic use. CDI incidence decreased from 11.2 to 4.8 per 1000 admissions, p =.03. Among patients who received antibiotics CDI incidence decreased from 2.2% to 0.7%, p =.01. Conclusions: We report the largest series of a CDI bundle implementation including probiotics. During the period of adoption of these interventions, the incidence of CDI decreased significantly.

KW - Clostridium difficile

KW - Infection

KW - Probiotic

KW - Trauma

UR - http://www.scopus.com/inward/record.url?scp=85042406071&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042406071&partnerID=8YFLogxK

U2 - 10.1016/j.amjsurg.2018.01.005

DO - 10.1016/j.amjsurg.2018.01.005

M3 - Article

C2 - 29490870

AN - SCOPUS:85042406071

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

ER -