Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci

Autism Sequencing Consortium

Research output: Contribution to journalArticle

392 Citations (Scopus)

Abstract

Analysis of de novo CNVs (dnCNVs) from the full Simons Simplex Collection (SSC) (N = 2,591 families) replicates prior findings of strong association with autism spectrum disorders (ASDs) and confirms six risk loci (1q21.1, 3q29, 7q11.23, 16p11.2, 15q11.2-13, and 22q11.2). The addition of published CNV data from the Autism Genome Project (AGP) and exome sequencing data from the SSC and the Autism Sequencing Consortium (ASC) shows that genes within small de novo deletions, but not within large dnCNVs, significantly overlap the high-effect risk genes identified by sequencing. Alternatively, large dnCNVs are found likely to contain multiple modest-effect risk genes. Overall, we find strong evidence that de novo mutations are associated with ASD apart from the risk for intellectual disability. Extending the transmission and de novo association test (TADA) to include small de novo deletions reveals 71 ASD risk loci, including 6 CNV regions (noted above) and 65 risk genes (FDR ≤ 0.1). Through analysis of de novo mutations in autism spectrum disorder (ASD), Sanders et al. find that small deletions, but not large deletions/duplications, contain one critical gene. Combining CNV and sequencing data, they identify 6 loci and 65 genes associated with ASD.

Original languageEnglish (US)
Pages (from-to)1215-1233
Number of pages19
JournalNeuron
Volume87
Issue number6
DOIs
StatePublished - Sep 23 2015

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Genes
Autistic Disorder
Exome
Mutation
Intellectual Disability
Autism Spectrum Disorder
Genome

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci. / Autism Sequencing Consortium.

In: Neuron, Vol. 87, No. 6, 23.09.2015, p. 1215-1233.

Research output: Contribution to journalArticle

Autism Sequencing Consortium. / Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci. In: Neuron. 2015 ; Vol. 87, No. 6. pp. 1215-1233.
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abstract = "Analysis of de novo CNVs (dnCNVs) from the full Simons Simplex Collection (SSC) (N = 2,591 families) replicates prior findings of strong association with autism spectrum disorders (ASDs) and confirms six risk loci (1q21.1, 3q29, 7q11.23, 16p11.2, 15q11.2-13, and 22q11.2). The addition of published CNV data from the Autism Genome Project (AGP) and exome sequencing data from the SSC and the Autism Sequencing Consortium (ASC) shows that genes within small de novo deletions, but not within large dnCNVs, significantly overlap the high-effect risk genes identified by sequencing. Alternatively, large dnCNVs are found likely to contain multiple modest-effect risk genes. Overall, we find strong evidence that de novo mutations are associated with ASD apart from the risk for intellectual disability. Extending the transmission and de novo association test (TADA) to include small de novo deletions reveals 71 ASD risk loci, including 6 CNV regions (noted above) and 65 risk genes (FDR ≤ 0.1). Through analysis of de novo mutations in autism spectrum disorder (ASD), Sanders et al. find that small deletions, but not large deletions/duplications, contain one critical gene. Combining CNV and sequencing data, they identify 6 loci and 65 genes associated with ASD.",
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