Inner ear pathology in the Palmerston North autoimmune strain mouse

Dennis Trune, Jane I. Morton, James P. Craven, Sean J. Traynor, Curt R. Mitchell

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The Palmerston North autoimmune strain mouse is a model for spontaneous systemic lupus erythematosus. Inner ear structure and function were examined during the onset and progression of systemic autoimmune disease to identify potentially correlated auditory system pathology. The onset of systemic disease occurred at 4 to 5 months of age and was characterized by elevated serum immune complexes, cryoglobulins, and antinuclear antibodies. Coincident with the onset of autoimmune disease was degeneration of the apical turn stria vascularis and outer hair cells. These cochlear changes progressed basal-ward. At 10 months of age, auditory brainstem response thresholds were elevated and the stria vascularis area was measurably smaller throughout the cochlea. Immunohistochemical staining showed immunoglobulin G deposits within the organ of Corti, the vas spirale of the basilar membrane, the scala tympani, and marrow cavities of the bony otic capsule. These results suggest that cochlear pathology may be immune mediated in this mouse, which would make the strain suitable for the study of the mechanisms relating inner ear abnormalities and autoimmune disease.

Original languageEnglish (US)
Pages (from-to)259-266
Number of pages8
JournalAmerican Journal of Otolaryngology--Head and Neck Medicine and Surgery
Volume12
Issue number5
DOIs
StatePublished - 1991

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Cochlea
Inner Ear
Stria Vascularis
Autoimmune Diseases
Pathology
Outer Auditory Hair Cells
Labyrinth Diseases
Scala Tympani
Basilar Membrane
Cryoglobulins
Organ of Corti
Brain Stem Auditory Evoked Potentials
Antinuclear Antibodies
Antigen-Antibody Complex
Systemic Lupus Erythematosus
Capsules
Ear
Immunoglobulin G
Bone Marrow
Staining and Labeling

Keywords

  • autoimmune disease
  • immunoglobulin
  • inner ear
  • Palmerston North mouse
  • pathology

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Inner ear pathology in the Palmerston North autoimmune strain mouse. / Trune, Dennis; Morton, Jane I.; Craven, James P.; Traynor, Sean J.; Mitchell, Curt R.

In: American Journal of Otolaryngology--Head and Neck Medicine and Surgery, Vol. 12, No. 5, 1991, p. 259-266.

Research output: Contribution to journalArticle

Trune, Dennis ; Morton, Jane I. ; Craven, James P. ; Traynor, Sean J. ; Mitchell, Curt R. / Inner ear pathology in the Palmerston North autoimmune strain mouse. In: American Journal of Otolaryngology--Head and Neck Medicine and Surgery. 1991 ; Vol. 12, No. 5. pp. 259-266.
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