Inner ear basic fibroblast growth factor in CBA/J, C3H/HeJ, and autoimmune Palmerston North mice

Andrew D. Pedersen, Jane I. Morton, Dennis Trune

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Basic fibroblast growth factor (bFGF) has a mitogenic effect on fibroblasts and osteoblasts for matrix proliferation and on endothelial cells for neovascularization. Because otic capsule osteogenesis in autoimmune disease subjects often involves abnormal matrix and vascular changes, bFGF may serve as a potential mediator for such bone disorders. To investigate this relationship, bFGF was evaluated in the Palmerston North autoimmune strain mouse, which develops otic capsule sclerotic lesions during the progression of its systemic disease. Inner ears from PN mice, along with control CBA/J and C3H/HeJ mice, were immunohistochemically stained with antibodies against bFGF to identify its presence and possible role in otic capsule disease. Although cells reactive for bFGF were observed along the lining of the otic capsule in all three strains, a significantly higher frequency was observed in the PN mice. Other sites of staining included connective tissue around the tensor tympani muscle and the geniculate ganglion. This identification of bFGF in the otic capsule raises the possibility that it may play some role in normal bone maintenance, as well as abnormal bone or connective tissue remodeling in autoimmune disease.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalHearing Research
Volume66
Issue number2
DOIs
StatePublished - 1993

Fingerprint

Fibroblast Growth Factor 2
Inner Ear
Capsules
Ear
Bone and Bones
Connective Tissue
Autoimmune Diseases
Tensor Tympani
Geniculate Ganglion
Ear Diseases
Inbred C3H Mouse
Osteoblasts
Osteogenesis
Blood Vessels
Endothelial Cells
Fibroblasts
Maintenance
Staining and Labeling
Muscles
Antibodies

Keywords

  • Autoimmune disease
  • Basic fibroblast growth factor
  • Bone lining cells
  • Inner ear
  • Osteogenesis
  • Palmerston North mouse

ASJC Scopus subject areas

  • Sensory Systems

Cite this

Inner ear basic fibroblast growth factor in CBA/J, C3H/HeJ, and autoimmune Palmerston North mice. / Pedersen, Andrew D.; Morton, Jane I.; Trune, Dennis.

In: Hearing Research, Vol. 66, No. 2, 1993, p. 253-259.

Research output: Contribution to journalArticle

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