Innate Immune signals in autoimmune and autoinflammatory uveitis

James (Jim) Rosenbaum, Hyun Woong Kim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Although traditionally the adaptive immune system has been viewed as the essential contributor to autoimmune diseases, the evidence implicating the innate immune system has grown considerably in recent years. Several multisystem inflammatory diseases affect the uvea and occur as a result of a mutation in a gene coding for a component of the innate immune system. Diseases associated with uveitis such as ankylosing spondylitis, sarcoidosis, Behcet's disease and inflammatory bowel disease can best be conceptually understood by hypotheses that consider microbial infection and innate immunity as contributing factors.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalInternational Reviews of Immunology
Volume32
Issue number1
DOIs
StatePublished - Feb 2013

Fingerprint

Uveitis
Immune System
Uvea
Behcet Syndrome
Ankylosing Spondylitis
Sarcoidosis
Inflammatory Bowel Diseases
Innate Immunity
Autoimmune Diseases
Mutation
Infection
Genes

Keywords

  • Ankylosing spondylitis
  • Behcet's disease
  • Inflammatory bowel disease
  • NOD2
  • Sarcoidosis
  • TLR

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Innate Immune signals in autoimmune and autoinflammatory uveitis. / Rosenbaum, James (Jim); Kim, Hyun Woong.

In: International Reviews of Immunology, Vol. 32, No. 1, 02.2013, p. 68-75.

Research output: Contribution to journalArticle

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