Innate Immune signals in autoimmune and autoinflammatory uveitis

James T. Rosenbaum, Hyun Woong Kim

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Although traditionally the adaptive immune system has been viewed as the essential contributor to autoimmune diseases, the evidence implicating the innate immune system has grown considerably in recent years. Several multisystem inflammatory diseases affect the uvea and occur as a result of a mutation in a gene coding for a component of the innate immune system. Diseases associated with uveitis such as ankylosing spondylitis, sarcoidosis, Behcet's disease and inflammatory bowel disease can best be conceptually understood by hypotheses that consider microbial infection and innate immunity as contributing factors.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalInternational reviews of immunology
Volume32
Issue number1
DOIs
StatePublished - Feb 1 2013

Keywords

  • Ankylosing spondylitis
  • Behcet's disease
  • Inflammatory bowel disease
  • NOD2
  • Sarcoidosis
  • TLR

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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