@article{305d0c7afb0e441bb333c4eb20bfd370,
title = "Innate immune sensing by epithelial barriers",
abstract = "Epithelial cells in barrier tissues perform a critical immune function by detecting, restricting, and often directly eliminating extrinsic pathogens. Membrane-bound and cytosolic pattern recognition receptors in epithelial cells bind to diverse ligands, detecting pathogen components and behaviors and stimulating cell-autonomous immunity. In addition to directly acting as first-responders to pathogens, epithelial cells detect commensal-derived and diet-derived products to promote homeostasis. Recent advances have clarified the array of molecular sensors expressed by epithelial cells, and how epithelial cells responses are wired to promote homeostatic balance while simultaneously allowing elimination of pathogens. These new studies emphatically position epithelial cells as central to an effective innate immune response.",
author = "Constant, {David A.} and Nice, {Timothy J.} and Isabella Rauch",
note = "Funding Information: We thank Madeline Churchill and Jacob Van Winkle for critical reading of the manuscript. The authors would like to acknowledge the colleagues whose work we were not able to cite due to the article format, or whom we may have inadvertently overlooked. This work was supported by the National Institutes of Health5T32AI007472-25 (DAC) and R01-AI130055 (TJN), and OHSU (IR, DAC). Funding Information: We thank Madeline Churchill and Jacob Van Winkle for critical reading of the manuscript. The authors would like to acknowledge the colleagues whose work we were not able to cite due to the article format, or whom we may have inadvertently overlooked. This work was supported by the National Institutes of Health 5T32AI007472-25 (DAC) and R01-AI130055 (TJN), and OHSU (IR, DAC). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
month = dec,
doi = "10.1016/j.coi.2021.07.014",
language = "English (US)",
volume = "73",
pages = "1--8",
journal = "Current Opinion in Immunology",
issn = "0952-7915",
publisher = "Elsevier Limited",
}