Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study

James C. Barton, R. T. Acton, L. Lovato, M. R. Speechley, C. E. McLaren, E. L. Harris, D. M. Reboussin, P. C. Adams, F. W. Dawkins, V. R. Gordeuk, A. P. Walker, Deborah Dixon, Susan Ferguson, Richard Jones, Jerry McKnight, Charles A. Rivers, Diane Tucker, Janice C. Ware, Gordon McLaren, Hoda Anton-CulverJo Ann A Baca, Thomas C. Bent, Lance C. Brunner, Michael M. Dao, Korey S. Jorgensen, Julie Kuniyoshi, Huan D. Le, Miles K. Masatsugu, Frank L. Meyskens, David Morohashi, Huan P. Nguyen, Sophocles N. Panagon, Chi Phung, Virgil Raymundo, Thomas Ton, Lari B. Wenzel, Argyrios Ziogas, Erin Bloch, Subrata Chakrabarti, Arlene Fleischhauer, Helen Harrison, Bonnie Hogan, Kelly Jia, John Jordan, Sheila Larson, Edward Lin, Melissa Lopez, Godfrey Moses, Lien Nguyen, Corry Pepper, Tara Power, Donald Sun, Diane Woelfle, Mikel Aickin, Elaine Baker, Marjorie Erwin, Joan Hulop, Carol Lloyd, Nancy Press, Richard Press, Jacob Reiss, Cheryl Ritenbaugh, Aileen Uchida, Thomas Vogt, Dwight Yim, Margaret Fadojutimi-Akinsiku, Oswaldo Castro, Debra White-Coleman, Melvin Gerald, Barbara W. Harrison, Ometha Lewis-Jack, Robert F. Murray, Shelley McDonald-Pinkett, Angela Rock, Juan Romagoza, Robert Williams, John H. Eckfeldt, Catherine Leiendecker-Foster, Ronald C. McGlennen, Greg Rynders, Michael Y. Tsai, Beverly M. Snively, Rogers Anderson, Elease Bostic, Brenda L. Craven, Shellie Ellis, Curt Furberg, Jason Griffin, Mark Hall, Darrin Harris, Leora Henkin, Sharon Jackson, Tamison Jewett, Mark D. King, Kurt Lohman, Joe Michaleckyi, Shana Palla, Tina Parks, Leah Passmore

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We compared initial screening transferrin saturation (TfSat) and serum ferritin (SF) phenotypes and HFE C282Y and H63D genotypes of 645 Native American and 43,453 white Hemochromatosis and Iron Overload Screening Study participants who did not report a previous diagnosis of hemochromatosis or iron overload. Elevated measurements were defined as TfSat >50% in men and >45% in women and SF>300 ng/ml in men and >200 ng/ml in women. Mean TfSat was 31% in Native American men and 32% in white men (p = 0.0337) and 25% in Native American women and 27% in white women (p <0.0001). Mean SF was 153 mg/l in Native American and 151 μ/l in white men (p = 0.8256); mean SF was 55 μ/l in Native American women and 63 μ/l in white women (p = 0.0015). The C282Y allele frequency was 0.0340 in Native Americans and 0.0683 in whites (p <0.0001). The H63D allele frequency was 0.1150 in Native Americans and 0.1532 in whites (p = 0.0001). We conclude that the screening TfSat and SF phenotypes of Native Americans are similar to those of whites. The allele frequencies of HFE C282Y and H63D are significantly lower in Native Americans than in whites.

Original languageEnglish (US)
Pages (from-to)48-57
Number of pages10
JournalClinical Genetics
Volume69
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Iron Overload
Hemochromatosis
North American Indians
Transferrin
Ferritins
Genotype
Serum
Gene Frequency
Phenotype

Keywords

  • Ferritin
  • Hemochromatosis
  • HFE
  • Iron overload
  • Transferrin saturation

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study. / Barton, James C.; Acton, R. T.; Lovato, L.; Speechley, M. R.; McLaren, C. E.; Harris, E. L.; Reboussin, D. M.; Adams, P. C.; Dawkins, F. W.; Gordeuk, V. R.; Walker, A. P.; Dixon, Deborah; Ferguson, Susan; Jones, Richard; McKnight, Jerry; Rivers, Charles A.; Tucker, Diane; Ware, Janice C.; McLaren, Gordon; Anton-Culver, Hoda; Baca, Jo Ann A; Bent, Thomas C.; Brunner, Lance C.; Dao, Michael M.; Jorgensen, Korey S.; Kuniyoshi, Julie; Le, Huan D.; Masatsugu, Miles K.; Meyskens, Frank L.; Morohashi, David; Nguyen, Huan P.; Panagon, Sophocles N.; Phung, Chi; Raymundo, Virgil; Ton, Thomas; Wenzel, Lari B.; Ziogas, Argyrios; Bloch, Erin; Chakrabarti, Subrata; Fleischhauer, Arlene; Harrison, Helen; Hogan, Bonnie; Jia, Kelly; Jordan, John; Larson, Sheila; Lin, Edward; Lopez, Melissa; Moses, Godfrey; Nguyen, Lien; Pepper, Corry; Power, Tara; Sun, Donald; Woelfle, Diane; Aickin, Mikel; Baker, Elaine; Erwin, Marjorie; Hulop, Joan; Lloyd, Carol; Press, Nancy; Press, Richard; Reiss, Jacob; Ritenbaugh, Cheryl; Uchida, Aileen; Vogt, Thomas; Yim, Dwight; Fadojutimi-Akinsiku, Margaret; Castro, Oswaldo; White-Coleman, Debra; Gerald, Melvin; Harrison, Barbara W.; Lewis-Jack, Ometha; Murray, Robert F.; McDonald-Pinkett, Shelley; Rock, Angela; Romagoza, Juan; Williams, Robert; Eckfeldt, John H.; Leiendecker-Foster, Catherine; McGlennen, Ronald C.; Rynders, Greg; Tsai, Michael Y.; Snively, Beverly M.; Anderson, Rogers; Bostic, Elease; Craven, Brenda L.; Ellis, Shellie; Furberg, Curt; Griffin, Jason; Hall, Mark; Harris, Darrin; Henkin, Leora; Jackson, Sharon; Jewett, Tamison; King, Mark D.; Lohman, Kurt; Michaleckyi, Joe; Palla, Shana; Parks, Tina; Passmore, Leah.

In: Clinical Genetics, Vol. 69, No. 1, 01.2006, p. 48-57.

Research output: Contribution to journalArticle

Barton, JC, Acton, RT, Lovato, L, Speechley, MR, McLaren, CE, Harris, EL, Reboussin, DM, Adams, PC, Dawkins, FW, Gordeuk, VR, Walker, AP, Dixon, D, Ferguson, S, Jones, R, McKnight, J, Rivers, CA, Tucker, D, Ware, JC, McLaren, G, Anton-Culver, H, Baca, JAA, Bent, TC, Brunner, LC, Dao, MM, Jorgensen, KS, Kuniyoshi, J, Le, HD, Masatsugu, MK, Meyskens, FL, Morohashi, D, Nguyen, HP, Panagon, SN, Phung, C, Raymundo, V, Ton, T, Wenzel, LB, Ziogas, A, Bloch, E, Chakrabarti, S, Fleischhauer, A, Harrison, H, Hogan, B, Jia, K, Jordan, J, Larson, S, Lin, E, Lopez, M, Moses, G, Nguyen, L, Pepper, C, Power, T, Sun, D, Woelfle, D, Aickin, M, Baker, E, Erwin, M, Hulop, J, Lloyd, C, Press, N, Press, R, Reiss, J, Ritenbaugh, C, Uchida, A, Vogt, T, Yim, D, Fadojutimi-Akinsiku, M, Castro, O, White-Coleman, D, Gerald, M, Harrison, BW, Lewis-Jack, O, Murray, RF, McDonald-Pinkett, S, Rock, A, Romagoza, J, Williams, R, Eckfeldt, JH, Leiendecker-Foster, C, McGlennen, RC, Rynders, G, Tsai, MY, Snively, BM, Anderson, R, Bostic, E, Craven, BL, Ellis, S, Furberg, C, Griffin, J, Hall, M, Harris, D, Henkin, L, Jackson, S, Jewett, T, King, MD, Lohman, K, Michaleckyi, J, Palla, S, Parks, T & Passmore, L 2006, 'Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study', Clinical Genetics, vol. 69, no. 1, pp. 48-57. https://doi.org/10.1111/j.1399-0004.2006.00553.x
Barton, James C. ; Acton, R. T. ; Lovato, L. ; Speechley, M. R. ; McLaren, C. E. ; Harris, E. L. ; Reboussin, D. M. ; Adams, P. C. ; Dawkins, F. W. ; Gordeuk, V. R. ; Walker, A. P. ; Dixon, Deborah ; Ferguson, Susan ; Jones, Richard ; McKnight, Jerry ; Rivers, Charles A. ; Tucker, Diane ; Ware, Janice C. ; McLaren, Gordon ; Anton-Culver, Hoda ; Baca, Jo Ann A ; Bent, Thomas C. ; Brunner, Lance C. ; Dao, Michael M. ; Jorgensen, Korey S. ; Kuniyoshi, Julie ; Le, Huan D. ; Masatsugu, Miles K. ; Meyskens, Frank L. ; Morohashi, David ; Nguyen, Huan P. ; Panagon, Sophocles N. ; Phung, Chi ; Raymundo, Virgil ; Ton, Thomas ; Wenzel, Lari B. ; Ziogas, Argyrios ; Bloch, Erin ; Chakrabarti, Subrata ; Fleischhauer, Arlene ; Harrison, Helen ; Hogan, Bonnie ; Jia, Kelly ; Jordan, John ; Larson, Sheila ; Lin, Edward ; Lopez, Melissa ; Moses, Godfrey ; Nguyen, Lien ; Pepper, Corry ; Power, Tara ; Sun, Donald ; Woelfle, Diane ; Aickin, Mikel ; Baker, Elaine ; Erwin, Marjorie ; Hulop, Joan ; Lloyd, Carol ; Press, Nancy ; Press, Richard ; Reiss, Jacob ; Ritenbaugh, Cheryl ; Uchida, Aileen ; Vogt, Thomas ; Yim, Dwight ; Fadojutimi-Akinsiku, Margaret ; Castro, Oswaldo ; White-Coleman, Debra ; Gerald, Melvin ; Harrison, Barbara W. ; Lewis-Jack, Ometha ; Murray, Robert F. ; McDonald-Pinkett, Shelley ; Rock, Angela ; Romagoza, Juan ; Williams, Robert ; Eckfeldt, John H. ; Leiendecker-Foster, Catherine ; McGlennen, Ronald C. ; Rynders, Greg ; Tsai, Michael Y. ; Snively, Beverly M. ; Anderson, Rogers ; Bostic, Elease ; Craven, Brenda L. ; Ellis, Shellie ; Furberg, Curt ; Griffin, Jason ; Hall, Mark ; Harris, Darrin ; Henkin, Leora ; Jackson, Sharon ; Jewett, Tamison ; King, Mark D. ; Lohman, Kurt ; Michaleckyi, Joe ; Palla, Shana ; Parks, Tina ; Passmore, Leah. / Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study. In: Clinical Genetics. 2006 ; Vol. 69, No. 1. pp. 48-57.
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abstract = "We compared initial screening transferrin saturation (TfSat) and serum ferritin (SF) phenotypes and HFE C282Y and H63D genotypes of 645 Native American and 43,453 white Hemochromatosis and Iron Overload Screening Study participants who did not report a previous diagnosis of hemochromatosis or iron overload. Elevated measurements were defined as TfSat >50{\%} in men and >45{\%} in women and SF>300 ng/ml in men and >200 ng/ml in women. Mean TfSat was 31{\%} in Native American men and 32{\%} in white men (p = 0.0337) and 25{\%} in Native American women and 27{\%} in white women (p <0.0001). Mean SF was 153 mg/l in Native American and 151 μ/l in white men (p = 0.8256); mean SF was 55 μ/l in Native American women and 63 μ/l in white women (p = 0.0015). The C282Y allele frequency was 0.0340 in Native Americans and 0.0683 in whites (p <0.0001). The H63D allele frequency was 0.1150 in Native Americans and 0.1532 in whites (p = 0.0001). We conclude that the screening TfSat and SF phenotypes of Native Americans are similar to those of whites. The allele frequencies of HFE C282Y and H63D are significantly lower in Native Americans than in whites.",
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TY - JOUR

T1 - Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in Native Americans and whites in the Hemochromatosis and Iron Overload Screening Study

AU - Barton, James C.

AU - Acton, R. T.

AU - Lovato, L.

AU - Speechley, M. R.

AU - McLaren, C. E.

AU - Harris, E. L.

AU - Reboussin, D. M.

AU - Adams, P. C.

AU - Dawkins, F. W.

AU - Gordeuk, V. R.

AU - Walker, A. P.

AU - Dixon, Deborah

AU - Ferguson, Susan

AU - Jones, Richard

AU - McKnight, Jerry

AU - Rivers, Charles A.

AU - Tucker, Diane

AU - Ware, Janice C.

AU - McLaren, Gordon

AU - Anton-Culver, Hoda

AU - Baca, Jo Ann A

AU - Bent, Thomas C.

AU - Brunner, Lance C.

AU - Dao, Michael M.

AU - Jorgensen, Korey S.

AU - Kuniyoshi, Julie

AU - Le, Huan D.

AU - Masatsugu, Miles K.

AU - Meyskens, Frank L.

AU - Morohashi, David

AU - Nguyen, Huan P.

AU - Panagon, Sophocles N.

AU - Phung, Chi

AU - Raymundo, Virgil

AU - Ton, Thomas

AU - Wenzel, Lari B.

AU - Ziogas, Argyrios

AU - Bloch, Erin

AU - Chakrabarti, Subrata

AU - Fleischhauer, Arlene

AU - Harrison, Helen

AU - Hogan, Bonnie

AU - Jia, Kelly

AU - Jordan, John

AU - Larson, Sheila

AU - Lin, Edward

AU - Lopez, Melissa

AU - Moses, Godfrey

AU - Nguyen, Lien

AU - Pepper, Corry

AU - Power, Tara

AU - Sun, Donald

AU - Woelfle, Diane

AU - Aickin, Mikel

AU - Baker, Elaine

AU - Erwin, Marjorie

AU - Hulop, Joan

AU - Lloyd, Carol

AU - Press, Nancy

AU - Press, Richard

AU - Reiss, Jacob

AU - Ritenbaugh, Cheryl

AU - Uchida, Aileen

AU - Vogt, Thomas

AU - Yim, Dwight

AU - Fadojutimi-Akinsiku, Margaret

AU - Castro, Oswaldo

AU - White-Coleman, Debra

AU - Gerald, Melvin

AU - Harrison, Barbara W.

AU - Lewis-Jack, Ometha

AU - Murray, Robert F.

AU - McDonald-Pinkett, Shelley

AU - Rock, Angela

AU - Romagoza, Juan

AU - Williams, Robert

AU - Eckfeldt, John H.

AU - Leiendecker-Foster, Catherine

AU - McGlennen, Ronald C.

AU - Rynders, Greg

AU - Tsai, Michael Y.

AU - Snively, Beverly M.

AU - Anderson, Rogers

AU - Bostic, Elease

AU - Craven, Brenda L.

AU - Ellis, Shellie

AU - Furberg, Curt

AU - Griffin, Jason

AU - Hall, Mark

AU - Harris, Darrin

AU - Henkin, Leora

AU - Jackson, Sharon

AU - Jewett, Tamison

AU - King, Mark D.

AU - Lohman, Kurt

AU - Michaleckyi, Joe

AU - Palla, Shana

AU - Parks, Tina

AU - Passmore, Leah

PY - 2006/1

Y1 - 2006/1

N2 - We compared initial screening transferrin saturation (TfSat) and serum ferritin (SF) phenotypes and HFE C282Y and H63D genotypes of 645 Native American and 43,453 white Hemochromatosis and Iron Overload Screening Study participants who did not report a previous diagnosis of hemochromatosis or iron overload. Elevated measurements were defined as TfSat >50% in men and >45% in women and SF>300 ng/ml in men and >200 ng/ml in women. Mean TfSat was 31% in Native American men and 32% in white men (p = 0.0337) and 25% in Native American women and 27% in white women (p <0.0001). Mean SF was 153 mg/l in Native American and 151 μ/l in white men (p = 0.8256); mean SF was 55 μ/l in Native American women and 63 μ/l in white women (p = 0.0015). The C282Y allele frequency was 0.0340 in Native Americans and 0.0683 in whites (p <0.0001). The H63D allele frequency was 0.1150 in Native Americans and 0.1532 in whites (p = 0.0001). We conclude that the screening TfSat and SF phenotypes of Native Americans are similar to those of whites. The allele frequencies of HFE C282Y and H63D are significantly lower in Native Americans than in whites.

AB - We compared initial screening transferrin saturation (TfSat) and serum ferritin (SF) phenotypes and HFE C282Y and H63D genotypes of 645 Native American and 43,453 white Hemochromatosis and Iron Overload Screening Study participants who did not report a previous diagnosis of hemochromatosis or iron overload. Elevated measurements were defined as TfSat >50% in men and >45% in women and SF>300 ng/ml in men and >200 ng/ml in women. Mean TfSat was 31% in Native American men and 32% in white men (p = 0.0337) and 25% in Native American women and 27% in white women (p <0.0001). Mean SF was 153 mg/l in Native American and 151 μ/l in white men (p = 0.8256); mean SF was 55 μ/l in Native American women and 63 μ/l in white women (p = 0.0015). The C282Y allele frequency was 0.0340 in Native Americans and 0.0683 in whites (p <0.0001). The H63D allele frequency was 0.1150 in Native Americans and 0.1532 in whites (p = 0.0001). We conclude that the screening TfSat and SF phenotypes of Native Americans are similar to those of whites. The allele frequencies of HFE C282Y and H63D are significantly lower in Native Americans than in whites.

KW - Ferritin

KW - Hemochromatosis

KW - HFE

KW - Iron overload

KW - Transferrin saturation

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