Initial in vivo evaluation of the DexAide right ventricular assist device

Yoshio Ootaki, Keiji Kamohara, Masatoshi Akiyama, Firas Zahr, Michael W. Kopcak, Raymond Dessoffy, Alex Massiello, David Horvath, Ji Feng Chen, Stephen Benefit, Leonard A.R. Golding, Kiyotaka Fukamachi

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8 Scopus citations

Abstract

Despite the increasing use of left ventricular assist devices for patients with end-stage congestive heart failure, no implantable, centrifugal right ventricular assist devices (RVADs) are available for those patients with significant right ventricular failure. The DexAide RVAD was developed to provide an implantable RVAD option to surgeons. The aim of this study was to evaluate pump performance in an acute in vivo model. The DexAide RVAD, developed as a modified CorAide left ventricular assist device, was implanted between the right ventricle and the pulmonary artery in four healthy calves. Pump speed was varied from 1800 rpm to 3600 rpm. RVAD performance was analyzed acutely at baseline and under conditions of low circulating volume, high contractility, high pulmonary arterial pressure, vasodilation, and low contractility. Pump flow was well maintained even under conditions of high pulmonary arterial pressure and vasodilation, with the exception of low circulating volume. Under all conditions, pulmonary arterial pressures were not affected by changing pump speed. The DexAide RVAD demonstrated acceptable hemodynamic characteristics for use as an implantable RVAD in the initial acute studies. Further studies are ongoing to examine the biocompatibility of the pump under chronic conditions.

Original languageEnglish (US)
Pages (from-to)739-742
Number of pages4
JournalASAIO Journal
Volume51
Issue number6
DOIs
StatePublished - Nov 1 2005

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ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Ootaki, Y., Kamohara, K., Akiyama, M., Zahr, F., Kopcak, M. W., Dessoffy, R., Massiello, A., Horvath, D., Chen, J. F., Benefit, S., Golding, L. A. R., & Fukamachi, K. (2005). Initial in vivo evaluation of the DexAide right ventricular assist device. ASAIO Journal, 51(6), 739-742. https://doi.org/10.1097/01.mat.0000187399.46756.fc