Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction

P (Hemachandra) Reddy

    Research output: Contribution to journalArticle

    64 Scopus citations

    Abstract

    Mitochondria are essential cytoplasmic organelles, critical for cell survival and death. Recent mitochondrial research revealed that mitochondrial dynamics - the balance of fission and fusion in normal mitochondrial dynamics - is an important cellular mechanism in eukaryotic cell and is involved in the maintenance of mitochondrial morphology, structure, number, distribution, and function. Research into mitochondria and cell function has revealed that mitochondrial dynamics is impaired in a large number of aging and neurodegenerative diseases, and in several inherited mitochondrial diseases, and that this impairment involves excessive mitochondrial fission, resulting in mitochondrial structural changes and dysfunction, and cell damage. Attempts have been made to develop molecules to reduce mitochondrial fission while maintaining normal mitochondrial fusion and function in those diseases that involve excessive mitochondrial fission. This review article discusses mechanisms of mitochondrial fission in normal and diseased states of mammalian cells and discusses research aimed at developing therapies, such as Mdivi, Dynasore and P110, to prevent or to inhibit excessive mitochondrial fission.

    Original languageEnglish (US)
    Pages (from-to)245-256
    Number of pages12
    JournalJournal of Alzheimer's Disease
    Volume40
    Issue number2
    DOIs
    Publication statusPublished - 2014

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    Keywords

    • Alzheimer's disease
    • fission inhibitors
    • free radical production
    • mitochondrial dynamics
    • mitochondrial dysfunction
    • oxidative stress

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Geriatrics and Gerontology
    • Clinical Psychology
    • Medicine(all)

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