Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma

Medicine & Life Sciences

• G1 Phase Cell Cycle Checkpoints 100%
• Hodgkin Disease 78%
• Phosphatidylinositol 3-Kinase 77%
• Reed-Sternberg Cells 54%
• Apoptosis 46%
• Phosphorylation 35%
• Caspase 9 28%
• CD30 Ligand 23%
• Receptor Activator of Nuclear Factor-kappa B 20%
• Ribosomal Protein S6 19%
• RANK Ligand 17%
• S 6 17%
• Chromosomes, Human, Pair 10 16%
• Tensins 16%
• CD40 Ligand 15%
• Cell Cycle Resting Phase 15%
• Poly(ADP-ribose) Polymerases 15%
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15%
• Cell Line 15%
• Cyclin D1 13%
• G1 Phase 13%
• Phosphoric Monoester Hydrolases 12%
• Cell Cycle Checkpoints 12%
• Up-Regulation 9%
• Lymph Nodes 9%
• Down-Regulation 8%
• Neoplasms 8%
• Growth 6%
• Therapeutics 2%