Inhibition of SUR1 decreases the vascular permeability of cerebral metastases

Eric M. Thompson, Gregory L. Pishko, Leslie Muldoon, Edward Neuwelt

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Inhibition of sulfonylurea receptor 1 (SUR1) by glyburide has been shown to decrease edema after subarachnoid hemorrhage. We investigated if inhibiting SUR1 reduces cerebral edema due to metastases, the most common brain tumor, and explored the putative association of SUR1 and the endothelial tight junction protein, zona occludens-1 (ZO-1). Nude rats were intracerebrally implanted with small cell lung carcinoma (SCLC) LX1 or A2058 melanoma cells (n = 36). Rats were administered vehicle, glyburide (4.8 μg twice, orally), or dexamethasone (0.35 mg, intravenous). Blood-tumor barrier (BTB) permeability (K trans) was evaluated before and after treatment using dynamic contrastenhanced magnetic resonance imaging. SUR1 and ZO-1 expression was evaluated using immunofluorescence and Western blots. In both models, SUR1 expression was significantly increased (P trans (percent change ± standard error) was 101.8 ± 36.6%, and both glyburide (-21.4 ± 14.2%, P .05). Both glyburide (P

Original languageEnglish (US)
Pages (from-to)535-543
Number of pages9
JournalNeoplasia (United States)
Volume15
Issue number5
DOIs
StatePublished - 2013

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Sulfonylurea Receptors
Capillary Permeability
Glyburide
Neoplasm Metastasis
Zonula Occludens-1 Protein
Nude Rats
Brain Edema
Small Cell Lung Carcinoma
Herpes Zoster
Subarachnoid Hemorrhage
Brain Neoplasms
Dexamethasone
Fluorescent Antibody Technique
Melanoma
Permeability
Edema
Western Blotting
Magnetic Resonance Imaging
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Medicine(all)

Cite this

Inhibition of SUR1 decreases the vascular permeability of cerebral metastases. / Thompson, Eric M.; Pishko, Gregory L.; Muldoon, Leslie; Neuwelt, Edward.

In: Neoplasia (United States), Vol. 15, No. 5, 2013, p. 535-543.

Research output: Contribution to journalArticle

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