Inhibition of Ocular Herpes Simplex Infection in Rabbits by Extracts of Burkitt's Lymphoma Cell Cultures

Daniel M. Albert; Alan S. Rabson

doi:10.3181/00379727-138-35841

Inhibition of Ocular Herpes Simplex Infection in Rabbits by Extracts of Burkitt's Lymphoma Cell Cultures

Daniel M. Albert, Alan S. Rabson

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Extracts of Burkitt's lymphoma cell cultures which had been previously shown to contain an inhibitor of herpes simplex virus in vitro were used to treat rabbits with ocular herpes infection. Topical instillation of the extract into the eyes of the rabbits cured or suppressed the progression of herpetic keratitis. Histopathologic studies of the eyes of treated and control animals confirmed the inhibition of keratitis and other evidence of herpes-related ocular inflammation.

Original language	English (US)
Pages (from-to)	108-111
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	138
Issue number	1
DOIs	https://doi.org/10.3181/00379727-138-35841
State	Published - Oct 1971
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3181/00379727-138-35841

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title = "Inhibition of Ocular Herpes Simplex Infection in Rabbits by Extracts of Burkitt's Lymphoma Cell Cultures",

abstract = "Extracts of Burkitt's lymphoma cell cultures which had been previously shown to contain an inhibitor of herpes simplex virus in vitro were used to treat rabbits with ocular herpes infection. Topical instillation of the extract into the eyes of the rabbits cured or suppressed the progression of herpetic keratitis. Histopathologic studies of the eyes of treated and control animals confirmed the inhibition of keratitis and other evidence of herpes-related ocular inflammation.",

author = "Albert, {Daniel M.} and Rabson, {Alan S.}",

note = "Funding Information: This work was supported by U.S. Public Health Service grant EY-00108-02.",

year = "1971",

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doi = "10.3181/00379727-138-35841",

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AU - Albert, Daniel M.

AU - Rabson, Alan S.

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PY - 1971/10

Y1 - 1971/10

N2 - Extracts of Burkitt's lymphoma cell cultures which had been previously shown to contain an inhibitor of herpes simplex virus in vitro were used to treat rabbits with ocular herpes infection. Topical instillation of the extract into the eyes of the rabbits cured or suppressed the progression of herpetic keratitis. Histopathologic studies of the eyes of treated and control animals confirmed the inhibition of keratitis and other evidence of herpes-related ocular inflammation.

AB - Extracts of Burkitt's lymphoma cell cultures which had been previously shown to contain an inhibitor of herpes simplex virus in vitro were used to treat rabbits with ocular herpes infection. Topical instillation of the extract into the eyes of the rabbits cured or suppressed the progression of herpetic keratitis. Histopathologic studies of the eyes of treated and control animals confirmed the inhibition of keratitis and other evidence of herpes-related ocular inflammation.

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Inhibition of Ocular Herpes Simplex Infection in Rabbits by Extracts of Burkitt's Lymphoma Cell Cultures

Abstract

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