Inhibition of HIV-1 Reverse Transcriptase-Catalyzed Synthesis by Intercalated DNA Benzo[a]Pyrene 7,8-Dihydrodiol-9,10-Epoxide Adducts

Agriculture & Biology

• Human immunodeficiency virus 1 67%
• RNA-directed DNA polymerase 65%
• benzo(a)pyrene 65%
• epoxides 51%
• synthesis 30%
• DNA 27%
• DNA adducts 18%
• stereoisomers 17%
• stereochemistry 16%
• adenine 14%
• nucleotides 9%

Medicine & Life Sciences

• benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA 100%
• 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 90%
• Human immunodeficiency virus 1 reverse transcriptase 75%
• HIV-1 38%
• DNA 18%
• Stereoisomerism 15%
• DNA Adducts 13%
• Adenine 12%
• Catalytic Domain 9%
• Nucleotides 8%

Chemical Compounds

• Benzo[a]pyrene 62%
• Adduct 39%
• Stereochemistry 11%
• Nucleotide 11%
• Kd 10%
• Dissociation 9%
• Block Like Crystal 9%
• Probe 8%