Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte

Carsten Grüllich, Robert M. Duvoisin, Martin Wiedmann, Klaus Van Leyen

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Mammalian cells are characterized by an endomembrane system. Nevertheless, some cells lose these membranes during their terminal differentiation, e.g. red blood cells and lens fiber cells of the eye. 15-Lipoxygenase is believed to be critical for this membrane degradation. Here we use cultivated rabbit reticulocytes in the presence or absence of a lipoxygenase inhibitor to provide further evidence for the importance of 15-lipoxygenase for the in vivo degradation of mitochondria. We find that inhibitor treatment retarded mitochondrial degradation, as shown by persistence of marker proteins and by direct visualization of mitochondria by electron microscopy.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalFEBS Letters
Volume489
Issue number1
DOIs
StatePublished - Jan 26 2001

Keywords

  • Eicosatetraynoic acid
  • Lipoxygenase
  • Mitochondrion
  • Organelle degradation
  • Red blood cell
  • Reticulocyte
  • Terminal differentiation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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