Abstract
Mammalian cells are characterized by an endomembrane system. Nevertheless, some cells lose these membranes during their terminal differentiation, e.g. red blood cells and lens fiber cells of the eye. 15-Lipoxygenase is believed to be critical for this membrane degradation. Here we use cultivated rabbit reticulocytes in the presence or absence of a lipoxygenase inhibitor to provide further evidence for the importance of 15-lipoxygenase for the in vivo degradation of mitochondria. We find that inhibitor treatment retarded mitochondrial degradation, as shown by persistence of marker proteins and by direct visualization of mitochondria by electron microscopy.
Original language | English (US) |
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Pages (from-to) | 51-54 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 489 |
Issue number | 1 |
DOIs | |
State | Published - Jan 26 2001 |
Externally published | Yes |
Keywords
- Eicosatetraynoic acid
- Lipoxygenase
- Mitochondrion
- Organelle degradation
- Red blood cell
- Reticulocyte
- Terminal differentiation
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology