Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain

Hideto Kitano, Jeffrey Kirsch, Patricia D. Hurn, Stephanie J. Murphy

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.

Original languageEnglish (US)
Pages (from-to)1108-1128
Number of pages21
JournalJournal of Cerebral Blood Flow and Metabolism
Volume27
Issue number6
DOIs
StatePublished - Jun 2007

Fingerprint

Neuroprotective Agents
Anesthetics
Brain
Brain Ischemia
Brain Injuries
Ischemic Preconditioning
Research
Neuroprotection

Keywords

  • Inhalational anesthesia
  • Neuroprotection
  • Perioperative stroke
  • Preconditioning

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

Cite this

Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain. / Kitano, Hideto; Kirsch, Jeffrey; Hurn, Patricia D.; Murphy, Stephanie J.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 27, No. 6, 06.2007, p. 1108-1128.

Research output: Contribution to journalArticle

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