Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain

Hideto Kitano; Jeffrey R. Kirsch; Patricia D. Hurn; Stephanie J. Murphy

doi:10.1038/sj.jcbfm.9600410

Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain

Hideto Kitano, Jeffrey R. Kirsch, Patricia D. Hurn, Stephanie J. Murphy

Research output: Contribution to journal › Review article › peer-review

173 Scopus citations

Abstract

This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.

Original language	English (US)
Pages (from-to)	1108-1128
Number of pages	21
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	27
Issue number	6
DOIs	https://doi.org/10.1038/sj.jcbfm.9600410
State	Published - Jun 2007
Externally published	Yes

Keywords

Inhalational anesthesia
Neuroprotection
Perioperative stroke
Preconditioning

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/sj.jcbfm.9600410

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abstract = "This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.",

keywords = "Inhalational anesthesia, Neuroprotection, Perioperative stroke, Preconditioning",

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AU - Hurn, Patricia D.

AU - Murphy, Stephanie J.

PY - 2007/6

Y1 - 2007/6

N2 - This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.

AB - This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.

KW - Inhalational anesthesia

KW - Neuroprotection

KW - Perioperative stroke

KW - Preconditioning

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ER -

Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain

Abstract

Keywords

ASJC Scopus subject areas

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