Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain

Hideto Kitano, Jeffrey R. Kirsch, Patricia D. Hurn, Stephanie J. Murphy

Research output: Contribution to journalReview article

141 Scopus citations

Abstract

This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and challenges of past and current research in this area will be addressed before reviewing experimental and clinical studies evaluating the effects of inhalational anesthetics before and during cerebral ischemia. Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed.

Original languageEnglish (US)
Pages (from-to)1108-1128
Number of pages21
JournalJournal of Cerebral Blood Flow and Metabolism
Volume27
Issue number6
DOIs
StatePublished - Jun 1 2007

Keywords

  • Inhalational anesthesia
  • Neuroprotection
  • Perioperative stroke
  • Preconditioning

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain'. Together they form a unique fingerprint.

  • Cite this