Inhalational anesthesia and histamine release during bronchospasm

J. M. Hermens, G. Edelstein, Jon Hanifin, W. R. Woodward, C. A. Hirshman

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Abstract

The influence of inhalational anesthetics on histamine released during bronchospasm induced by Ascaris antigen aerosol was studied in Basenji-Greyhound (BG) dogs. Five BG dogs were anesthetized with thiopental and halothane on separate occasions and challenged with Ascaris antigen aerosol for five minutes. Pulmonary resistance (R(L)), dynamic compliance (C(dyn)), and arterial plasma histamine levels were measured over 30 min following antigen exposure. Prior to antigen challenge, R(L), C(dyn), and histamine levels were similar in thiopental- and halothane-anesthetized dogs. The peak change in R(L) and C(dyn) occurred 10 min after the start of antigen challenge. R(L) increased 3.0 ± 0.4-fold (mean ± SEM) in thiopental-anesthetized dogs as compared with 1.6 ± 0.2-fold in halothane-anesthetized dogs (P

Original languageEnglish (US)
Pages (from-to)69-72
Number of pages4
JournalAnesthesiology
Volume61
Issue number1
Publication statusPublished - 1984

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ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Hermens, J. M., Edelstein, G., Hanifin, J., Woodward, W. R., & Hirshman, C. A. (1984). Inhalational anesthesia and histamine release during bronchospasm. Anesthesiology, 61(1), 69-72.