Infusion of bovine parathyroid hormone1-34 attenuates the pressor response to angiotensin II in spontaneously hypertensive rats

David Ellison, David A. McCarron

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Parathyroid hormone, long known to be important for calcium homeostasis, also has potent vascular effects. In the past, pharmacologic doses of parathyroid hormone or its active amino-terminal fragment (PTH1-34) were necessary to demonstrate vaso-activity. We assessed the vascular effects of physiologic doses of infused synthetic bovine PTH1-34 (15 U/hr or 1.5 μg/hr) on the pressor response to angiotensin II. PTH1-34 attenuated the pressor response (p1-34 dampened the pressor response by as much as 33% These results suggest that endogenous PTH may modulate systemic blood pressure and regional vascular resistance. In various states of parathyroid gland stimulation, the peptide may exert physiologically important vascular effects.

Original languageEnglish (US)
Pages (from-to)1637-1647
Number of pages11
JournalClinical and Experimental Hypertension
VolumeA4
Issue number9-10
DOIs
StatePublished - 1982

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Inbred SHR Rats
Angiotensin II
Blood Vessels
Parathyroid Hormone
Parathyroid Glands
Vascular Resistance
Homeostasis
Blood Pressure
Calcium
Peptides

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Infusion of bovine parathyroid hormone1-34 attenuates the pressor response to angiotensin II in spontaneously hypertensive rats. / Ellison, David; McCarron, David A.

In: Clinical and Experimental Hypertension, Vol. A4, No. 9-10, 1982, p. 1637-1647.

Research output: Contribution to journalArticle

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