TY - JOUR
T1 - Infrared neural stimulation of primary visual cortex in non-human primates
AU - Cayce, Jonathan M.
AU - Friedman, Robert M.
AU - Chen, Gang
AU - Jansen, E. Duco
AU - Mahadevan-Jansen, Anita
AU - Roe, Anna W.
N1 - Funding Information:
The authors would like to acknowledge Mary R. Feurtado and Yasmina A. Paramastri for animal care and Andrea Brock, Brian Lustig, Jeremy Winberry, and Lisa Chu for experimental assistance. This work was supported by the National Institutes of Health (NIH R01 NS052407-01 , NS44375 , and MH095009 ), DOD-MFEL Program ( DOD/AFOSR F49620-01-1-4029 ), Vanderbilt Center for Integrative and Cognitive Neuroscience , and the Human Frontiers Science Program .
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Infrared neural stimulation (INS) is an alternative neurostimulation modality that uses pulsed infrared light to evoke spatially precise neural activity that does not require direct contact with neural tissue. With these advantages INS has the potential to increase our understanding of specific neural pathways and impact current diagnostic and therapeutic clinical applications. In order to develop this technique, we investigate the feasibility of INS (λ = 1.875. μm, fiber diameter = 100-400. μm) to activate and modulate neural activity in primary visual cortex (V1) of Macaque monkeys. Infrared neural stimulation was found to evoke localized neural responses as evidenced by both electrophysiology and intrinsic signal optical imaging (OIS). Single unit recordings acquired during INS indicated statistically significant increases in neuron firing rates that demonstrate INS evoked excitatory neural activity. Consistent with this, INS stimulation led to focal intensity-dependent reflectance changes recorded with OIS. We also asked whether INS is capable of stimulating functionally specific domains in visual cortex and of modulating visually evoked activity in visual cortex. We found that application of INS via 100. μm or 200. μm fiber optics produced enhancement of visually evoked OIS response confined to the eye column where INS was applied and relative suppression of the other eye column. Stimulating the cortex with a 400. μm fiber, exceeding the ocular dominance width, led to relative suppression, consistent with involvement of inhibitory surrounds. This study is the first to demonstrate that INS can be used to either enhance or diminish visual cortical response and that this can be done in a functional domain specific manner. INS thus holds great potential for use as a safe, non-contact, focally specific brain stimulation technology in primate brains.
AB - Infrared neural stimulation (INS) is an alternative neurostimulation modality that uses pulsed infrared light to evoke spatially precise neural activity that does not require direct contact with neural tissue. With these advantages INS has the potential to increase our understanding of specific neural pathways and impact current diagnostic and therapeutic clinical applications. In order to develop this technique, we investigate the feasibility of INS (λ = 1.875. μm, fiber diameter = 100-400. μm) to activate and modulate neural activity in primary visual cortex (V1) of Macaque monkeys. Infrared neural stimulation was found to evoke localized neural responses as evidenced by both electrophysiology and intrinsic signal optical imaging (OIS). Single unit recordings acquired during INS indicated statistically significant increases in neuron firing rates that demonstrate INS evoked excitatory neural activity. Consistent with this, INS stimulation led to focal intensity-dependent reflectance changes recorded with OIS. We also asked whether INS is capable of stimulating functionally specific domains in visual cortex and of modulating visually evoked activity in visual cortex. We found that application of INS via 100. μm or 200. μm fiber optics produced enhancement of visually evoked OIS response confined to the eye column where INS was applied and relative suppression of the other eye column. Stimulating the cortex with a 400. μm fiber, exceeding the ocular dominance width, led to relative suppression, consistent with involvement of inhibitory surrounds. This study is the first to demonstrate that INS can be used to either enhance or diminish visual cortical response and that this can be done in a functional domain specific manner. INS thus holds great potential for use as a safe, non-contact, focally specific brain stimulation technology in primate brains.
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U2 - 10.1016/j.neuroimage.2013.08.040
DO - 10.1016/j.neuroimage.2013.08.040
M3 - Article
C2 - 23994125
AN - SCOPUS:84884165910
SN - 1053-8119
VL - 84
SP - 181
EP - 190
JO - NeuroImage
JF - NeuroImage
ER -