Influence of weight training on skeletal health of breast cancer survivors with or at risk for breast cancer-related lymphedema

Kerri Winters-Stone, Monica Laudermilk, Kaitlin Woo, Justin C. Brown, Kathryn H. Schmitz

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Purpose: This study aimed to determine whether the Physical Activity and Lymphedema (PAL) trial weight training program for breast cancer survivors at risk of or with breast cancer-related lymphedema provided skeletal benefits. Methods: Of the 295 participants in the randomized controlled PAL trial, 258 (weight training; N = 128; control, N = 130) had complete measures of bone mineral density (BMD (in grams per square centimeter)) of the proximal femur and lumbar spine and were also categorized by T scores. Women in the weight training group performed slowly progressive weight training 2 days/week for 12 months compared to women in the control group who maintained their usual physical activities. Results: There were no significant differences in the rate of BMD change at any skeletal site between weight training and control groups, regardless of menopausal status. Distribution of bone health categories was not significantly different between groups at baseline, but became different at 12 months (p <0.03) among postmenopausal women due to an increase in the percentage of controls who became osteopenic (35 to 44 %) compared to stable bone health in weight lifters. Conclusions: The PAL weight training program that increased muscle strength without exacerbating or causing lymphedema among breast cancer survivors was not as efficacious at improving skeletal health. The skeletal loads produced from the PAL program may be insufficient to notably shift BMD, but may have a subtle osteogenic effect. Implications for cancer survivors: The safety and efficacy of rigorous weight training programs for improving skeletal health in women at risk for or with breast cancer-related lymphedema remain to be determined.

Original languageEnglish (US)
Pages (from-to)260-268
Number of pages9
JournalJournal of Cancer Survivorship
Volume8
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Survivors
Breast Neoplasms
Weights and Measures
Lymphedema
Health
Exercise
Education
Bone and Bones
Control Groups
Breast Cancer Lymphedema
Muscle Strength
Women's Health
Bone Density
Femur
Spine
Safety
Neoplasms

Keywords

  • Fractures
  • Neoplasms
  • Osteoporosis
  • Resistance exercise
  • Survivorship

ASJC Scopus subject areas

  • Oncology
  • Oncology(nursing)
  • Medicine(all)

Cite this

Influence of weight training on skeletal health of breast cancer survivors with or at risk for breast cancer-related lymphedema. / Winters-Stone, Kerri; Laudermilk, Monica; Woo, Kaitlin; Brown, Justin C.; Schmitz, Kathryn H.

In: Journal of Cancer Survivorship, Vol. 8, No. 2, 2014, p. 260-268.

Research output: Contribution to journalArticle

Winters-Stone, Kerri ; Laudermilk, Monica ; Woo, Kaitlin ; Brown, Justin C. ; Schmitz, Kathryn H. / Influence of weight training on skeletal health of breast cancer survivors with or at risk for breast cancer-related lymphedema. In: Journal of Cancer Survivorship. 2014 ; Vol. 8, No. 2. pp. 260-268.
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abstract = "Purpose: This study aimed to determine whether the Physical Activity and Lymphedema (PAL) trial weight training program for breast cancer survivors at risk of or with breast cancer-related lymphedema provided skeletal benefits. Methods: Of the 295 participants in the randomized controlled PAL trial, 258 (weight training; N = 128; control, N = 130) had complete measures of bone mineral density (BMD (in grams per square centimeter)) of the proximal femur and lumbar spine and were also categorized by T scores. Women in the weight training group performed slowly progressive weight training 2 days/week for 12 months compared to women in the control group who maintained their usual physical activities. Results: There were no significant differences in the rate of BMD change at any skeletal site between weight training and control groups, regardless of menopausal status. Distribution of bone health categories was not significantly different between groups at baseline, but became different at 12 months (p <0.03) among postmenopausal women due to an increase in the percentage of controls who became osteopenic (35 to 44 {\%}) compared to stable bone health in weight lifters. Conclusions: The PAL weight training program that increased muscle strength without exacerbating or causing lymphedema among breast cancer survivors was not as efficacious at improving skeletal health. The skeletal loads produced from the PAL program may be insufficient to notably shift BMD, but may have a subtle osteogenic effect. Implications for cancer survivors: The safety and efficacy of rigorous weight training programs for improving skeletal health in women at risk for or with breast cancer-related lymphedema remain to be determined.",
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