Abstract
The severity of many diseases varies by time of day. For example, adverse cardiovascular incidents peak in the morning, asthma is often worse at night, and temporal lobe epileptic seizures are most prevalent in the afternoon. These patterns may be due to the day/night rhythm in environment and behavior, or endogenous circadian rhythms in physiology, or a combination of both. Furthermore, chronic misalignment between the endogenous circadian timing system and the behavioral cycles could be a cause of increased risk of diabetes, obesity, cardiovascular disease, and certain cancers in shift workers. This article describes the magnitude, relevance, and potential biologic basis of such daily changes in disease severity and of circadian/behavioral misalignment, and presents how these insights may help in the development of appropriate chronotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-163 |
| Number of pages | 21 |
| Journal | Sleep Medicine Clinics |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2009 |
| Externally published | Yes |
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Keywords
- Asthma
- Cardiovascular
- Chronotherapy
- Circadian
- Epilepsy
- Sleep
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuropsychology and Physiological Psychology
- Clinical Psychology
- Clinical Neurology
Cite this
Influence of the Circadian System on Disease Severity. / Litinski, Mikhail; Scheer, Frank A J L; Shea, Steven.
In: Sleep Medicine Clinics, Vol. 4, No. 2, 06.2009, p. 143-163.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of the Circadian System on Disease Severity
AU - Litinski, Mikhail
AU - Scheer, Frank A J L
AU - Shea, Steven
PY - 2009/6
Y1 - 2009/6
N2 - The severity of many diseases varies by time of day. For example, adverse cardiovascular incidents peak in the morning, asthma is often worse at night, and temporal lobe epileptic seizures are most prevalent in the afternoon. These patterns may be due to the day/night rhythm in environment and behavior, or endogenous circadian rhythms in physiology, or a combination of both. Furthermore, chronic misalignment between the endogenous circadian timing system and the behavioral cycles could be a cause of increased risk of diabetes, obesity, cardiovascular disease, and certain cancers in shift workers. This article describes the magnitude, relevance, and potential biologic basis of such daily changes in disease severity and of circadian/behavioral misalignment, and presents how these insights may help in the development of appropriate chronotherapy.
AB - The severity of many diseases varies by time of day. For example, adverse cardiovascular incidents peak in the morning, asthma is often worse at night, and temporal lobe epileptic seizures are most prevalent in the afternoon. These patterns may be due to the day/night rhythm in environment and behavior, or endogenous circadian rhythms in physiology, or a combination of both. Furthermore, chronic misalignment between the endogenous circadian timing system and the behavioral cycles could be a cause of increased risk of diabetes, obesity, cardiovascular disease, and certain cancers in shift workers. This article describes the magnitude, relevance, and potential biologic basis of such daily changes in disease severity and of circadian/behavioral misalignment, and presents how these insights may help in the development of appropriate chronotherapy.
KW - Asthma
KW - Cardiovascular
KW - Chronotherapy
KW - Circadian
KW - Epilepsy
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=66549129438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66549129438&partnerID=8YFLogxK
U2 - 10.1016/j.jsmc.2009.02.005
DO - 10.1016/j.jsmc.2009.02.005
M3 - Article
AN - SCOPUS:66549129438
VL - 4
SP - 143
EP - 163
JO - Sleep Medicine Clinics
JF - Sleep Medicine Clinics
SN - 1556-407X
IS - 2
ER -