TY - JOUR
T1 - Influence of the Circadian System on Disease Severity
AU - Litinski, Mikhail
AU - Scheer, Frank A.J.L.
AU - Shea, Steven A.
N1 - Funding Information:
This work was supported by grant K24 HL76446 from the National Institutes of Health to SA Shea, by grant R21 AT002713 from the National Institutes of Health to FAJL Scheer, and by grant 43-PA-08 from the American Sleep Medicine Foundation (a foundation of the American Academy of Sleep Medicine) to M Litinski.
PY - 2009/6
Y1 - 2009/6
N2 - The severity of many diseases varies by time of day. For example, adverse cardiovascular incidents peak in the morning, asthma is often worse at night, and temporal lobe epileptic seizures are most prevalent in the afternoon. These patterns may be due to the day/night rhythm in environment and behavior, or endogenous circadian rhythms in physiology, or a combination of both. Furthermore, chronic misalignment between the endogenous circadian timing system and the behavioral cycles could be a cause of increased risk of diabetes, obesity, cardiovascular disease, and certain cancers in shift workers. This article describes the magnitude, relevance, and potential biologic basis of such daily changes in disease severity and of circadian/behavioral misalignment, and presents how these insights may help in the development of appropriate chronotherapy.
AB - The severity of many diseases varies by time of day. For example, adverse cardiovascular incidents peak in the morning, asthma is often worse at night, and temporal lobe epileptic seizures are most prevalent in the afternoon. These patterns may be due to the day/night rhythm in environment and behavior, or endogenous circadian rhythms in physiology, or a combination of both. Furthermore, chronic misalignment between the endogenous circadian timing system and the behavioral cycles could be a cause of increased risk of diabetes, obesity, cardiovascular disease, and certain cancers in shift workers. This article describes the magnitude, relevance, and potential biologic basis of such daily changes in disease severity and of circadian/behavioral misalignment, and presents how these insights may help in the development of appropriate chronotherapy.
KW - Asthma
KW - Cardiovascular
KW - Chronotherapy
KW - Circadian
KW - Epilepsy
KW - Sleep
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U2 - 10.1016/j.jsmc.2009.02.005
DO - 10.1016/j.jsmc.2009.02.005
M3 - Review article
AN - SCOPUS:66549129438
SN - 1556-407X
VL - 4
SP - 143
EP - 163
JO - Sleep Medicine Clinics
JF - Sleep Medicine Clinics
IS - 2
ER -