Influence of serum blocking factors on cancer patients undergoing immunotherapy

R. Mark Vetto, Denis R. Burger, Arthur Vandenbark, James Nolte

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Blocking factors are small polypeptide molecules that may appear in the serum of patients with cancer. These factors block the transformation of lymphocytes in culture to nonspecific mitogens such as phytohemagglutinin or concanavalin A and, therefore, may reflect changes in the immunocompetence of the patient. Blocking factors were monitored during the clinical course of thirty-five patients with cancer. These factors did not develop in patients with response to therapy whereas they did develop in patients without response. A third group of patients without response to therapy after a previous remission showed an absence of lymphocyte responsiveness in culture that was not due to blocking factors, suggesting that immune clone consumption had occurred. Dermal responsiveness to tumor antigen correlated with a favorable clinical course and was usually absent when serum blocking factors were present.

Original languageEnglish (US)
Pages (from-to)237-243
Number of pages7
JournalThe American Journal of Surgery
Volume130
Issue number2
DOIs
StatePublished - 1975
Externally publishedYes

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Immunotherapy
Serum
Neoplasms
Immunocompetence
Phytohemagglutinins
Neoplasm Antigens
Lymphocyte Activation
Concanavalin A
Mitogens
blocking factor
Clone Cells
Lymphocytes
Skin
Peptides
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Influence of serum blocking factors on cancer patients undergoing immunotherapy. / Vetto, R. Mark; Burger, Denis R.; Vandenbark, Arthur; Nolte, James.

In: The American Journal of Surgery, Vol. 130, No. 2, 1975, p. 237-243.

Research output: Contribution to journalArticle

Vetto, R. Mark ; Burger, Denis R. ; Vandenbark, Arthur ; Nolte, James. / Influence of serum blocking factors on cancer patients undergoing immunotherapy. In: The American Journal of Surgery. 1975 ; Vol. 130, No. 2. pp. 237-243.
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