Influence of prenatal d-amphetamine administration on development and behavior of rats

Barbara A. Hitzemann, Robert J. Hitzemann, David A. Brase, Horace H. Loh

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Beginning on the fifth day of gestation, rats were administered 1 or 3 mg/kg of d-amphetamine sulfate s.c. twice daily until term. The administration of d-amphetamine caused a dose-related increase in pup mortality. However, the increase in pup death could not be correlated with any gross pathological signs. The surviving 3 mg/kg amphetamine pups were analyzed for changes in motor behavior and brain biogenic amine levels. It was found that the amphetamine offspring showed a marked reduction in the ability to habituate to new surroundings, and this effect persisted for at least three months after birth. On day 35, brain levels of norepinephrine in the "amphetamine" offspring were decreased 21 percent. On day 84, in the "amphetamine offspring," norepinephrine levels were reduced 18 percent in both the diencephalon and brainstem; dopamine levels were reduced 21 percent in the brainstem compared to control offspring.

Original languageEnglish (US)
Pages (from-to)605-612
Number of pages8
JournalLife Sciences
Issue number6
StatePublished - Mar 15 1976
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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