Influence of morphine on protein synthesis in discrete subcellular fractions of the rat brain

R. J. Hitzemann, H. H. Loh

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Extensive time course (15 min to 24 hr) measurements were made of the effects of acute and chronic morphine treatment on the incorporation of 3H lysine into rat brain proteins. Acute and chronic morphine treatment inhibited cortical protein synthesis in the microsomal (Mc), mitochondrial (Mw) and soluble fractions (Sol.). In the subcortex, acute morphine stimulated labelled protein accumulation in the Mc and Mw fractions. Chronic morphine treatment decreased 3H lys protein accumulation in these fractions.

Original languageEnglish (US)
Pages (from-to)237-248
Number of pages12
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume14
Issue number2
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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