TY - JOUR
T1 - Influence of microbubble shell properties on ultrasound signal
T2 - Implications for low-power perfusion imaging
AU - Leong-Poi, Howard
AU - Song, Ji
AU - Rim, Se Joong
AU - Christiansen, Jonathan
AU - Kaul, Sanjiv
AU - Lindner, Jonathan R.
N1 - Funding Information:
Dr Leong-Poi is the recipient of a fellowship training grant from the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada, Ottawa, Canada. Dr Christiansen is the recipient of a postdoctoral fellowship training grant from the Atlantic Coast Affiliate of the American Heart Association, Baltimore, Md. This study was also supported by grants to Dr Lindner (K08-HL-03810) and Dr Kaul (R01-HL-65704 and 3R01-HL-48890) from the National Institutes of Health, Bethesda, Md.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Low mechanical index perfusion imaging relies on the detection of signals produced by microbubble oscillation at low acoustic powers that results in minimal microbubble destruction. We hypothesized that the optimal acoustic power for real-time imaging would differ for microbubbles with different shell characteristics. Three microbubble agents with varying shell elastic properties according to their polymer composition were studied. Differences in the elastic properties of these microbubbles was demonstrated by: (1) measurement of their bulk modulus and (2) evaluation of their acoustic lability by microscopic visualization of microbubble destruction during insonification at incremental acoustic powers. The ultrasound signal generated by these microbubbles at various mechanical indexes and the degree of microbubble destruction during continuous imaging was determined both in an in vitro flow system and during in vivo imaging in an open-chest canine model. Both studies indicated that optimal power for achieving maximal signal intensity with minimal microbubble destruction was influenced by the shell elastic properties. We conclude that the acoustic power for maximizing acoustic signal without destroying microbubbles during low mechanical index imaging varies according to shell characteristics.
AB - Low mechanical index perfusion imaging relies on the detection of signals produced by microbubble oscillation at low acoustic powers that results in minimal microbubble destruction. We hypothesized that the optimal acoustic power for real-time imaging would differ for microbubbles with different shell characteristics. Three microbubble agents with varying shell elastic properties according to their polymer composition were studied. Differences in the elastic properties of these microbubbles was demonstrated by: (1) measurement of their bulk modulus and (2) evaluation of their acoustic lability by microscopic visualization of microbubble destruction during insonification at incremental acoustic powers. The ultrasound signal generated by these microbubbles at various mechanical indexes and the degree of microbubble destruction during continuous imaging was determined both in an in vitro flow system and during in vivo imaging in an open-chest canine model. Both studies indicated that optimal power for achieving maximal signal intensity with minimal microbubble destruction was influenced by the shell elastic properties. We conclude that the acoustic power for maximizing acoustic signal without destroying microbubbles during low mechanical index imaging varies according to shell characteristics.
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U2 - 10.1067/mje.2002.124516
DO - 10.1067/mje.2002.124516
M3 - Article
C2 - 12411916
AN - SCOPUS:0036782527
SN - 0894-7317
VL - 15
SP - 1269
EP - 1276
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 10 II
ER -