TY - JOUR
T1 - Influence of healing time on the outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft
T2 - A randomized clinical trial
AU - Couso-Queiruga, Emilio
AU - Weber, Holly A.
AU - Garaicoa-Pazmino, Carlos
AU - Barwacz, Christopher
AU - Kalleme, Marisa
AU - Galindo-Moreno, Pablo
AU - Avila-Ortiz, Gustavo
N1 - Publisher Copyright:
© 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
PY - 2023/2
Y1 - 2023/2
N2 - Aim: To evaluate the healing outcomes in non-molar post-extraction sockets filled with deproteinized bovine bone mineral with collagen (DBBM-C) as a function of time. Materials and Methods: Patients in need of non-molar tooth extraction were randomly allocated into one of three groups according to the total healing time (A—3 months; B—6 months; C—9 months). The effect of alveolar ridge preservation (ARP) therapy via socket filling using DBBM-C and socket sealing with a porcine collagen matrix (CM) was assessed based on a panel of clinical, digital, histomorphometric, implant-related, and patient-reported outcomes. Results: A total of 42 patients completed the study (n = 14 in each group). Histomorphometric analysis of bone core biopsies obtained at the time of implant placement showed a continuous increase in the proportion of mineralized tissue with respect to non-mineralized tissue, and a decrease in the proportion of remaining xenograft material over time. All volumetric bone and soft tissue contour assessments revealed a dimensional reduction of the alveolar ridge overtime affecting mainly the facial aspect. Linear regression analyses indicated that baseline buccal bone thickness is a strong predictor of bone and soft tissue modelling. Ancillary bone augmentation at the time of implant placement was needed in 16.7% of the sites (A:2; B:1; C:4). Patient-reported discomfort and wound healing index scores progressively decreased over time and was similar across groups. Conclusions: Healing time influences the proportion of tissue compartments in non-molar post-extraction sites filled with DBBM-C and sealed with a CM. A variable degree of alveolar ridge atrophy, affecting mainly the facial aspect, occurs even after performing ARP therapy. These changes are more pronounced in sites exhibiting thin facial bone (≤1 mm) at baseline (Clinicaltrials.gov NCT03659617).
AB - Aim: To evaluate the healing outcomes in non-molar post-extraction sockets filled with deproteinized bovine bone mineral with collagen (DBBM-C) as a function of time. Materials and Methods: Patients in need of non-molar tooth extraction were randomly allocated into one of three groups according to the total healing time (A—3 months; B—6 months; C—9 months). The effect of alveolar ridge preservation (ARP) therapy via socket filling using DBBM-C and socket sealing with a porcine collagen matrix (CM) was assessed based on a panel of clinical, digital, histomorphometric, implant-related, and patient-reported outcomes. Results: A total of 42 patients completed the study (n = 14 in each group). Histomorphometric analysis of bone core biopsies obtained at the time of implant placement showed a continuous increase in the proportion of mineralized tissue with respect to non-mineralized tissue, and a decrease in the proportion of remaining xenograft material over time. All volumetric bone and soft tissue contour assessments revealed a dimensional reduction of the alveolar ridge overtime affecting mainly the facial aspect. Linear regression analyses indicated that baseline buccal bone thickness is a strong predictor of bone and soft tissue modelling. Ancillary bone augmentation at the time of implant placement was needed in 16.7% of the sites (A:2; B:1; C:4). Patient-reported discomfort and wound healing index scores progressively decreased over time and was similar across groups. Conclusions: Healing time influences the proportion of tissue compartments in non-molar post-extraction sites filled with DBBM-C and sealed with a CM. A variable degree of alveolar ridge atrophy, affecting mainly the facial aspect, occurs even after performing ARP therapy. These changes are more pronounced in sites exhibiting thin facial bone (≤1 mm) at baseline (Clinicaltrials.gov NCT03659617).
KW - alveolar ridge preservation
KW - bone resorption
KW - dental implants
KW - digital image processing
KW - tooth extraction
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U2 - 10.1111/jcpe.13744
DO - 10.1111/jcpe.13744
M3 - Article
C2 - 36345818
AN - SCOPUS:85142284215
SN - 0303-6979
VL - 50
SP - 132
EP - 146
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
IS - 2
ER -