TY - JOUR
T1 - Influence of healing time on the outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft
T2 - A randomized clinical trial
AU - Couso-Queiruga, Emilio
AU - Weber, Holly A.
AU - Garaicoa-Pazmino, Carlos
AU - Barwacz, Christopher
AU - Kalleme, Marisa
AU - Galindo-Moreno, Pablo
AU - Avila-Ortiz, Gustavo
N1 - Funding Information:
This study was supported by a grant from Geistlich Pharma AG, Wolhusen, Switzerland.
Funding Information:
The authors would like to thank Ms Sara Miller, research manager and clinical coordinator at the Iowa Institute for Oral Health Research, and Dr Shareef M. Dabdoub, Assistant Professor in the Department of Periodontics at the University of Iowa College of Dentistry, for their efforts and support during the study.
Publisher Copyright:
© 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
PY - 2022
Y1 - 2022
N2 - Aim: To evaluate the healing outcomes in non-molar post-extraction sockets filled with deproteinized bovine bone mineral with collagen (DBBM-C) as a function of time. Materials and Methods: Patients in need of non-molar tooth extraction were randomly allocated into one of three groups according to the total healing time (A—3 months; B—6 months; C—9 months). The effect of alveolar ridge preservation (ARP) therapy via socket filling using DBBM-C and socket sealing with a porcine collagen matrix (CM) was assessed based on a panel of clinical, digital, histomorphometric, implant-related, and patient-reported outcomes. Results: A total of 42 patients completed the study (n = 14 in each group). Histomorphometric analysis of bone core biopsies obtained at the time of implant placement showed a continuous increase in the proportion of mineralized tissue with respect to non-mineralized tissue, and a decrease in the proportion of remaining xenograft material over time. All volumetric bone and soft tissue contour assessments revealed a dimensional reduction of the alveolar ridge overtime affecting mainly the facial aspect. Linear regression analyses indicated that baseline buccal bone thickness is a strong predictor of bone and soft tissue modelling. Ancillary bone augmentation at the time of implant placement was needed in 16.7% of the sites (A:2; B:1; C:4). Patient-reported discomfort and wound healing index scores progressively decreased over time and was similar across groups. Conclusions: Healing time influences the proportion of tissue compartments in non-molar post-extraction sites filled with DBBM-C and sealed with a CM. A variable degree of alveolar ridge atrophy, affecting mainly the facial aspect, occurs even after performing ARP therapy. These changes are more pronounced in sites exhibiting thin facial bone (≤1 mm) at baseline (Clinicaltrials.gov NCT03659617).
AB - Aim: To evaluate the healing outcomes in non-molar post-extraction sockets filled with deproteinized bovine bone mineral with collagen (DBBM-C) as a function of time. Materials and Methods: Patients in need of non-molar tooth extraction were randomly allocated into one of three groups according to the total healing time (A—3 months; B—6 months; C—9 months). The effect of alveolar ridge preservation (ARP) therapy via socket filling using DBBM-C and socket sealing with a porcine collagen matrix (CM) was assessed based on a panel of clinical, digital, histomorphometric, implant-related, and patient-reported outcomes. Results: A total of 42 patients completed the study (n = 14 in each group). Histomorphometric analysis of bone core biopsies obtained at the time of implant placement showed a continuous increase in the proportion of mineralized tissue with respect to non-mineralized tissue, and a decrease in the proportion of remaining xenograft material over time. All volumetric bone and soft tissue contour assessments revealed a dimensional reduction of the alveolar ridge overtime affecting mainly the facial aspect. Linear regression analyses indicated that baseline buccal bone thickness is a strong predictor of bone and soft tissue modelling. Ancillary bone augmentation at the time of implant placement was needed in 16.7% of the sites (A:2; B:1; C:4). Patient-reported discomfort and wound healing index scores progressively decreased over time and was similar across groups. Conclusions: Healing time influences the proportion of tissue compartments in non-molar post-extraction sites filled with DBBM-C and sealed with a CM. A variable degree of alveolar ridge atrophy, affecting mainly the facial aspect, occurs even after performing ARP therapy. These changes are more pronounced in sites exhibiting thin facial bone (≤1 mm) at baseline (Clinicaltrials.gov NCT03659617).
KW - alveolar ridge preservation
KW - bone resorption
KW - dental implants
KW - digital image processing
KW - tooth extraction
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U2 - 10.1111/jcpe.13744
DO - 10.1111/jcpe.13744
M3 - Article
C2 - 36345818
AN - SCOPUS:85142284215
VL - 50
SP - 132
EP - 146
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
SN - 0303-6979
IS - 2
ER -