Influence of globus pallidus on arm movements in monkeys. I. Effects of kainic acid-induced lesions

Fay Horak, M. E. Anderson

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

The role of basal ganglia output via the globus pallidus (GP) was examined in monkeys trained to make rapid arm-reaching movements to a visual target in a reaction time task. When neurons in the globus pallidus were destroyed by injection of kainic acid (KA) during task execution, contralateral arm movement times (MT) were increased significantly, with little or no change in reaction times (RT). The slowed movements were associated with a generalized depression in the amplitude and rate of rise of electromyographic (EMG) activity in all the contralateral muscles studied at the wrist, elbow, shoulder, and back, but there was no change in the sequential activation of these muscles. The most profound and persistant increases in movement time occurred when neurons were destroyed in the ventrolateral and caudal aspects of the internal as well as external pallidal segment. These results suggest a role for globus pallidus output in scaling the magnitude and/or buildup of EMG activity without affecting the initiation or the sequential organization of the programmed motor output.

Original languageEnglish (US)
Pages (from-to)290-304
Number of pages15
JournalJournal of Neurophysiology
Volume52
Issue number2
StatePublished - 1984
Externally publishedYes

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Globus Pallidus
Kainic Acid
Haplorhini
Arm
Neurons
Muscles
Elbow
Basal Ganglia
Wrist
Injections

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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Influence of globus pallidus on arm movements in monkeys. I. Effects of kainic acid-induced lesions. / Horak, Fay; Anderson, M. E.

In: Journal of Neurophysiology, Vol. 52, No. 2, 1984, p. 290-304.

Research output: Contribution to journalArticle

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