TY - JOUR
T1 - Influence of fitness status on very-low-density lipoprotein subfractions and lipoprotein(a) in men and women
AU - Thomas, Tom R.
AU - Ziogas, George
AU - Harris, William S.
N1 - Funding Information:
From the Exercise Physiology Laboratory, University of Missouri-Columbia, Columbia; and the Cardiovascular Research Laboratory, University of Missouri-Kansas City, Kansas City, MO. Submitted Nevember 30, 1996; accepted April 8, 1997. Supported by a University of Missouri Board grant and University of Missouri-Columbia Research Council Grant No. URC-O72-ER. Address reprint requests to Tom R. Thomas, PhD, 104 Rothwell Gym, Nutritional Sciences Program, University of Missouri-Columbia, Columbia, MO 65211. Copyright © 1997 by W.B. Saunders Company 0026-0495/97/4610-0015503.00/0
PY - 1997
Y1 - 1997
N2 - The purpose of this study was to examine the influence of the physical activity level of men and women on the very-low-density lipoprotein (VLDL) subfractions and lipoprotein(a) [Lp(a)]. Fifty-four men (n = 30) and women (n = 24) aged 30 to 53 years were recruited based on their level of activity over the past 2 years, and formed three groups: sedentary (S), no routine activity; recreational exercise (R), routine moderate exercise three to five times per week; and trained (T), competition-based, high-volume aerobic training five to seven times per week. Each subject underwent a maximal oxygen consumption (VO2max) test and was measured for body composition (skinfolds) and waist to hip ratio (WHR). Following a prescribed 24-hour diet and abstinence from activity, a blood sample was obtained from each subject and the plasma was analyzed for cholesterol and triglycerides (TGs) in VLDL1, VLDL2, and VLDL3 subfractions. High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and Lp(a) also were analyzed. Total VLDL-C was higher in men than in women, but no gender differences were observed in VLDL subfractions. VLDL1-TG and VLDL2-TG were elevated in the S group compared with groups R and T, even though total VLDL- TG, LDL-C, and HDL-C values were not different among the groups. Values for Lp(a) were not significantly different between men and women or among the groups. The two exercising groups were not different on any lipoprotein variable or WHR. VLDL1-TG was inversely correlated with VO2max and HDL-C. These results suggest that life-style activity is associated with a favorable VLDL subfraction pattern and WHR, but not Lp(a). In addition, long-term recreational activity is associated with a lipoprotein profile and WHR similar to those obtained with higher-volume exercise training.
AB - The purpose of this study was to examine the influence of the physical activity level of men and women on the very-low-density lipoprotein (VLDL) subfractions and lipoprotein(a) [Lp(a)]. Fifty-four men (n = 30) and women (n = 24) aged 30 to 53 years were recruited based on their level of activity over the past 2 years, and formed three groups: sedentary (S), no routine activity; recreational exercise (R), routine moderate exercise three to five times per week; and trained (T), competition-based, high-volume aerobic training five to seven times per week. Each subject underwent a maximal oxygen consumption (VO2max) test and was measured for body composition (skinfolds) and waist to hip ratio (WHR). Following a prescribed 24-hour diet and abstinence from activity, a blood sample was obtained from each subject and the plasma was analyzed for cholesterol and triglycerides (TGs) in VLDL1, VLDL2, and VLDL3 subfractions. High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and Lp(a) also were analyzed. Total VLDL-C was higher in men than in women, but no gender differences were observed in VLDL subfractions. VLDL1-TG and VLDL2-TG were elevated in the S group compared with groups R and T, even though total VLDL- TG, LDL-C, and HDL-C values were not different among the groups. Values for Lp(a) were not significantly different between men and women or among the groups. The two exercising groups were not different on any lipoprotein variable or WHR. VLDL1-TG was inversely correlated with VO2max and HDL-C. These results suggest that life-style activity is associated with a favorable VLDL subfraction pattern and WHR, but not Lp(a). In addition, long-term recreational activity is associated with a lipoprotein profile and WHR similar to those obtained with higher-volume exercise training.
UR - http://www.scopus.com/inward/record.url?scp=0030827869&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030827869&partnerID=8YFLogxK
U2 - 10.1016/S0026-0495(97)90213-4
DO - 10.1016/S0026-0495(97)90213-4
M3 - Article
C2 - 9322803
AN - SCOPUS:0030827869
SN - 0026-0495
VL - 46
SP - 1178
EP - 1183
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 10
ER -