Influence of developmental auditory deprivation on neuronal ultrastructure in the mouse anteroventral cochlear nucleus

Dennis Trune, Chris R. Morgan

Research output: Contribution to journalArticle

Abstract

Developmental auditory deprivation caused mouse anteroventral cochlear nucleus neurons to have significantly fewer auditory nerve terminals and more non-auditory nerve terminals. This suggested that stimulation regulated the developmental arborization of auditory nerve terminals and competition for synaptic space. Intracellularly, mitochondria were smaller and darker in the deprived neurons and appeared less active metabolically. Interference with these neuronal processes may underlie the impaired development seen in auditory deprivation.

Original languageEnglish (US)
Pages (from-to)304-308
Number of pages5
JournalDevelopmental Brain Research
Volume42
Issue number2
DOIs
StatePublished - Aug 1 1988

Fingerprint

Cochlear Nucleus
Cochlear Nerve
Neurons
Presynaptic Terminals
Mitochondria

Keywords

  • Auditory deprivation
  • Cochlear nucleus
  • Development
  • Genetic expression
  • Metabolism
  • Morphometry
  • Neuronal organelle
  • Synaptic competition

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Influence of developmental auditory deprivation on neuronal ultrastructure in the mouse anteroventral cochlear nucleus. / Trune, Dennis; Morgan, Chris R.

In: Developmental Brain Research, Vol. 42, No. 2, 01.08.1988, p. 304-308.

Research output: Contribution to journalArticle

@article{7c3ab9c588ff44b6b48890c8b60fa754,
title = "Influence of developmental auditory deprivation on neuronal ultrastructure in the mouse anteroventral cochlear nucleus",
abstract = "Developmental auditory deprivation caused mouse anteroventral cochlear nucleus neurons to have significantly fewer auditory nerve terminals and more non-auditory nerve terminals. This suggested that stimulation regulated the developmental arborization of auditory nerve terminals and competition for synaptic space. Intracellularly, mitochondria were smaller and darker in the deprived neurons and appeared less active metabolically. Interference with these neuronal processes may underlie the impaired development seen in auditory deprivation.",
keywords = "Auditory deprivation, Cochlear nucleus, Development, Genetic expression, Metabolism, Morphometry, Neuronal organelle, Synaptic competition",
author = "Dennis Trune and Morgan, {Chris R.}",
year = "1988",
month = "8",
day = "1",
doi = "10.1016/0165-3806(88)90249-0",
language = "English (US)",
volume = "42",
pages = "304--308",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Influence of developmental auditory deprivation on neuronal ultrastructure in the mouse anteroventral cochlear nucleus

AU - Trune, Dennis

AU - Morgan, Chris R.

PY - 1988/8/1

Y1 - 1988/8/1

N2 - Developmental auditory deprivation caused mouse anteroventral cochlear nucleus neurons to have significantly fewer auditory nerve terminals and more non-auditory nerve terminals. This suggested that stimulation regulated the developmental arborization of auditory nerve terminals and competition for synaptic space. Intracellularly, mitochondria were smaller and darker in the deprived neurons and appeared less active metabolically. Interference with these neuronal processes may underlie the impaired development seen in auditory deprivation.

AB - Developmental auditory deprivation caused mouse anteroventral cochlear nucleus neurons to have significantly fewer auditory nerve terminals and more non-auditory nerve terminals. This suggested that stimulation regulated the developmental arborization of auditory nerve terminals and competition for synaptic space. Intracellularly, mitochondria were smaller and darker in the deprived neurons and appeared less active metabolically. Interference with these neuronal processes may underlie the impaired development seen in auditory deprivation.

KW - Auditory deprivation

KW - Cochlear nucleus

KW - Development

KW - Genetic expression

KW - Metabolism

KW - Morphometry

KW - Neuronal organelle

KW - Synaptic competition

UR - http://www.scopus.com/inward/record.url?scp=0023696374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023696374&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(88)90249-0

DO - 10.1016/0165-3806(88)90249-0

M3 - Article

VL - 42

SP - 304

EP - 308

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 2

ER -