Influence of computer-aided detection on performance of screening mammography

Joshua J. Fenton, Stephen H. Taplin, Patricia (Patty) Carney, Linn Abraham, Edward A. Sickles, Carl D'Orsi, Eric A. Berns, Gary Cutter, R. Edward Hendrick, William E. Barlow, Joann G. Elmore

Research output: Contribution to journalArticle

316 Citations (Scopus)

Abstract

Background: Computer-aided detection identifies suspicious findings on mammograms to assist radiologists. Since the Food and Drug Administration approved the technology in 1998, it has been disseminated into practice, but its effect on the accuracy of interpretation is unclear. Methods: We determined the association between the use of computer-aided detection at mammography facilities and the performance of screening mammography from 1998 through 2002 at 43 facilities in three states. We had complete data for 222,135 women (a total of 429,345 mammograms), including 2351 women who received a diagnosis of breast cancer within 1 year after screening. We calculated the specificity, sensitivity, and positive predictive value of screening mammography with and without computer-aided detection, as well as the rates of biopsy and breast-cancer detection and the overall accuracy, measured as the area under the receiver-operating-characteristic (ROC) curve. Results: Seven facilities (16%) implemented computer-aided detection during the study period. Diagnostic specificity decreased from 90.2% before implementation to 87.2% after implementation (P

Original languageEnglish (US)
Pages (from-to)1399-1409
Number of pages11
JournalNew England Journal of Medicine
Volume356
Issue number14
DOIs
StatePublished - Apr 5 2007

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Mammography
Breast Neoplasms
United States Food and Drug Administration
ROC Curve
Technology
Biopsy
Sensitivity and Specificity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fenton, J. J., Taplin, S. H., Carney, P. P., Abraham, L., Sickles, E. A., D'Orsi, C., ... Elmore, J. G. (2007). Influence of computer-aided detection on performance of screening mammography. New England Journal of Medicine, 356(14), 1399-1409. https://doi.org/10.1056/NEJMoa066099

Influence of computer-aided detection on performance of screening mammography. / Fenton, Joshua J.; Taplin, Stephen H.; Carney, Patricia (Patty); Abraham, Linn; Sickles, Edward A.; D'Orsi, Carl; Berns, Eric A.; Cutter, Gary; Hendrick, R. Edward; Barlow, William E.; Elmore, Joann G.

In: New England Journal of Medicine, Vol. 356, No. 14, 05.04.2007, p. 1399-1409.

Research output: Contribution to journalArticle

Fenton, JJ, Taplin, SH, Carney, PP, Abraham, L, Sickles, EA, D'Orsi, C, Berns, EA, Cutter, G, Hendrick, RE, Barlow, WE & Elmore, JG 2007, 'Influence of computer-aided detection on performance of screening mammography', New England Journal of Medicine, vol. 356, no. 14, pp. 1399-1409. https://doi.org/10.1056/NEJMoa066099
Fenton, Joshua J. ; Taplin, Stephen H. ; Carney, Patricia (Patty) ; Abraham, Linn ; Sickles, Edward A. ; D'Orsi, Carl ; Berns, Eric A. ; Cutter, Gary ; Hendrick, R. Edward ; Barlow, William E. ; Elmore, Joann G. / Influence of computer-aided detection on performance of screening mammography. In: New England Journal of Medicine. 2007 ; Vol. 356, No. 14. pp. 1399-1409.
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