Influence of antihypertensive therapy on development and progression of diabetic glomerulopathy

Sharon Anderson, B. M. Brenner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Capillary hypertension is suggested to be the underlying cause of microvascular disease affecting the kidney, the retina, and other organs and tissues in diabetic patients and animals. Hyperglycemia causes an expansion of extracellular volume, which induces a vasodilatory response. Hemodynamic adaptation to vasodilation leads to an increase in intracapillary hydraulic pressure, which subsequently causes vascular damage. In experimental animals, restoration of capillary pressure to normal levels by ingestion of a low-protein diet or administration of an angiotensin I-converting enzyme inhibitor has been shown to prevent microvascular damage in the kidney, and dietary protein restriction limits injury in the retina as well. Atrial natriuretic peptide, which is secreted by atrial myocytes in response to volume expansion, may be involved in mediation of the hemodynamic adaptation (vasodilatory response) that results in diabetic microvascular disease.

Original languageEnglish (US)
Pages (from-to)846-849
Number of pages4
JournalDiabetes Care
Volume11
Issue number10
StatePublished - 1988
Externally publishedYes

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Antihypertensive Agents
Retina
Hemodynamics
Pressure
Protein-Restricted Diet
Dietary Proteins
Kidney Diseases
Atrial Natriuretic Factor
Angiotensin-Converting Enzyme Inhibitors
Vasodilation
Hyperglycemia
Muscle Cells
Blood Vessels
Eating
Hypertension
Kidney
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Influence of antihypertensive therapy on development and progression of diabetic glomerulopathy. / Anderson, Sharon; Brenner, B. M.

In: Diabetes Care, Vol. 11, No. 10, 1988, p. 846-849.

Research output: Contribution to journalArticle

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