Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex

Peter Jacobs, Dawn Konrad-Martin, Garnett P. McMillan, Daniel McDermott, Stephen A. Fausti, David Kagen, Eric A. Wan

Research output: Contribution to journalArticle

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Abstract

Stimulus-frequency (SF) otoacoustic emission (OAE) amplitude and the amplitude of medial olivocochlear (MOC) inhibition of SF OAEs for ipsilateral, contralateral and bilateral MOC reflex elicitors were recorded in six subjects with type 2 diabetes during a glucose tolerance test (GTT). Five of the six subjects were tested twice for a total of 11 trials and three subjects were tested in a control experiment. During the GTT experiment, the subjects' blood glucose was elevated from a euglycemic level below 150 mg/dL to a hyperglycemic level above 160 mg/dL following the consumption of a bolus of 80 g of sugar. A subset of three subjects were tested in a control experiment during which SF OAE and MOC reflex measurements were made while blood sugar levels remained constant within the euglycemic region. Mean SF OAE amplitudes were elevated following glucose consumption. A statistically significant increase in MOC inhibition amplitude was observed during elevated sugar levels for the 11 GTT trials. Maximum inhibition occurred about an hour after glucose consumption when blood glucose levels peaked. Results indicate that acute hyperglycemia influences efferent control of the cochlea in people with type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1296-1306
Number of pages11
JournalJournal of the Acoustical Society of America
Volume131
Issue number2
DOIs
StatePublished - Feb 2012

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hyperglycemia
reflexes
glucose
stimuli
sugars
blood
cochlea
Stimulus
Reflex
set theory
Tolerance
Blood
Experiment

ASJC Scopus subject areas

  • Acoustics and Ultrasonics
  • Arts and Humanities (miscellaneous)

Cite this

Jacobs, P., Konrad-Martin, D., McMillan, G. P., McDermott, D., Fausti, S. A., Kagen, D., & Wan, E. A. (2012). Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex. Journal of the Acoustical Society of America, 131(2), 1296-1306. https://doi.org/10.1121/1.3676609

Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex. / Jacobs, Peter; Konrad-Martin, Dawn; McMillan, Garnett P.; McDermott, Daniel; Fausti, Stephen A.; Kagen, David; Wan, Eric A.

In: Journal of the Acoustical Society of America, Vol. 131, No. 2, 02.2012, p. 1296-1306.

Research output: Contribution to journalArticle

Jacobs, P, Konrad-Martin, D, McMillan, GP, McDermott, D, Fausti, SA, Kagen, D & Wan, EA 2012, 'Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex', Journal of the Acoustical Society of America, vol. 131, no. 2, pp. 1296-1306. https://doi.org/10.1121/1.3676609
Jacobs, Peter ; Konrad-Martin, Dawn ; McMillan, Garnett P. ; McDermott, Daniel ; Fausti, Stephen A. ; Kagen, David ; Wan, Eric A. / Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex. In: Journal of the Acoustical Society of America. 2012 ; Vol. 131, No. 2. pp. 1296-1306.
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