Inflammatory response after influenza vaccination in men with and without carotid artery disease

Cara L. Carty, Patrick Heagerty, Karen Nakayama, E. Clair McClung, Julieann Lewis, Dawn Lum, Erin Boespflug, Carrie McCloud-Gehring, Behrooz R. Soleimani, Jane Ranchalis, Tamara J. Bacus, Clement E. Furlong, Gail P. Jarvik

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


OBJECTIVE - Inflammatory markers are associated with vascular disease; however, variation in the acute phase response (APR) has not been evaluated. We evaluated whether the APR magnitude in men with severe carotid artery disease (CAAD) (>80% stenosis) differed from that of men without stenosis (<15% stenosis). METHODS AND RESULTS - White males with (n=43) and without (n=61) severe CAAD receiving clinical influenza vaccinations were recruited. Their baseline and 24-hour after -vaccination blood samples were assayed for C-reactive protein (CRP), IL-6, and serum amyloid-a (SAA). In vivo APR to vaccination was measurable and varied among subjects. Adjusted for age, smoking, oral hypoglycemics, aspirin, and stain use, the relative 24-hour changes in levels of ln(CRP), ln(IL-6), and ln(SAA) were higher in men with CAAD than in men without, but only the SAA response was significant (P=0.02); the relative SAA response was 1.6 (95% confidence interval, 1.1 to 2.5) times higher in men with than without CAAD. The APR for all markers appeared to be independent of baseline levels. CONCLUSIONS - Influenza vaccination results in a mild, but measurable, APR in men with and without CAAD. SAA APR variability may be a predictor of severe vascular disease that is independent of basal SAA level.

Original languageEnglish (US)
Pages (from-to)2738-2744
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number12
StatePublished - Dec 2006
Externally publishedYes


  • Acute phase response
  • Carotid artery disease
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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