Inflammatory response after influenza vaccination in men with and without carotid artery disease

Cara L. Carty, Patrick Heagerty, Karen Nakayama, E. Clair McClung, Julieann Lewis, Dawn Lum, Erin Boespflug, Carrie McCloud-Gehring, Behrooz R. Soleimani, Jane Ranchalis, Tamara J. Bacus, Clement E. Furlong, Gail P. Jarvik

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

OBJECTIVE - Inflammatory markers are associated with vascular disease; however, variation in the acute phase response (APR) has not been evaluated. We evaluated whether the APR magnitude in men with severe carotid artery disease (CAAD) (>80% stenosis) differed from that of men without stenosis (<15% stenosis). METHODS AND RESULTS - White males with (n=43) and without (n=61) severe CAAD receiving clinical influenza vaccinations were recruited. Their baseline and 24-hour after -vaccination blood samples were assayed for C-reactive protein (CRP), IL-6, and serum amyloid-a (SAA). In vivo APR to vaccination was measurable and varied among subjects. Adjusted for age, smoking, oral hypoglycemics, aspirin, and stain use, the relative 24-hour changes in levels of ln(CRP), ln(IL-6), and ln(SAA) were higher in men with CAAD than in men without, but only the SAA response was significant (P=0.02); the relative SAA response was 1.6 (95% confidence interval, 1.1 to 2.5) times higher in men with than without CAAD. The APR for all markers appeared to be independent of baseline levels. CONCLUSIONS - Influenza vaccination results in a mild, but measurable, APR in men with and without CAAD. SAA APR variability may be a predictor of severe vascular disease that is independent of basal SAA level.

Original languageEnglish (US)
Pages (from-to)2738-2744
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Volume26
Issue number12
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

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Acute-Phase Reaction
Carotid Artery Diseases
Amyloid
Human Influenza
Vaccination
Serum
Pathologic Constriction
Vascular Diseases
C-Reactive Protein
Interleukin-6
Hypoglycemic Agents
Aspirin
Coloring Agents
Smoking
Confidence Intervals

Keywords

  • Acute phase response
  • Carotid artery disease
  • Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Inflammatory response after influenza vaccination in men with and without carotid artery disease. / Carty, Cara L.; Heagerty, Patrick; Nakayama, Karen; McClung, E. Clair; Lewis, Julieann; Lum, Dawn; Boespflug, Erin; McCloud-Gehring, Carrie; Soleimani, Behrooz R.; Ranchalis, Jane; Bacus, Tamara J.; Furlong, Clement E.; Jarvik, Gail P.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, No. 12, 01.12.2006, p. 2738-2744.

Research output: Contribution to journalArticle

Carty, CL, Heagerty, P, Nakayama, K, McClung, EC, Lewis, J, Lum, D, Boespflug, E, McCloud-Gehring, C, Soleimani, BR, Ranchalis, J, Bacus, TJ, Furlong, CE & Jarvik, GP 2006, 'Inflammatory response after influenza vaccination in men with and without carotid artery disease', Arteriosclerosis, thrombosis, and vascular biology, vol. 26, no. 12, pp. 2738-2744. https://doi.org/10.1161/01.ATV.0000248534.30057.b5
Carty, Cara L. ; Heagerty, Patrick ; Nakayama, Karen ; McClung, E. Clair ; Lewis, Julieann ; Lum, Dawn ; Boespflug, Erin ; McCloud-Gehring, Carrie ; Soleimani, Behrooz R. ; Ranchalis, Jane ; Bacus, Tamara J. ; Furlong, Clement E. ; Jarvik, Gail P. / Inflammatory response after influenza vaccination in men with and without carotid artery disease. In: Arteriosclerosis, thrombosis, and vascular biology. 2006 ; Vol. 26, No. 12. pp. 2738-2744.
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abstract = "OBJECTIVE - Inflammatory markers are associated with vascular disease; however, variation in the acute phase response (APR) has not been evaluated. We evaluated whether the APR magnitude in men with severe carotid artery disease (CAAD) (>80{\%} stenosis) differed from that of men without stenosis (<15{\%} stenosis). METHODS AND RESULTS - White males with (n=43) and without (n=61) severe CAAD receiving clinical influenza vaccinations were recruited. Their baseline and 24-hour after -vaccination blood samples were assayed for C-reactive protein (CRP), IL-6, and serum amyloid-a (SAA). In vivo APR to vaccination was measurable and varied among subjects. Adjusted for age, smoking, oral hypoglycemics, aspirin, and stain use, the relative 24-hour changes in levels of ln(CRP), ln(IL-6), and ln(SAA) were higher in men with CAAD than in men without, but only the SAA response was significant (P=0.02); the relative SAA response was 1.6 (95{\%} confidence interval, 1.1 to 2.5) times higher in men with than without CAAD. The APR for all markers appeared to be independent of baseline levels. CONCLUSIONS - Influenza vaccination results in a mild, but measurable, APR in men with and without CAAD. SAA APR variability may be a predictor of severe vascular disease that is independent of basal SAA level.",
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AU - Carty, Cara L.

AU - Heagerty, Patrick

AU - Nakayama, Karen

AU - McClung, E. Clair

AU - Lewis, Julieann

AU - Lum, Dawn

AU - Boespflug, Erin

AU - McCloud-Gehring, Carrie

AU - Soleimani, Behrooz R.

AU - Ranchalis, Jane

AU - Bacus, Tamara J.

AU - Furlong, Clement E.

AU - Jarvik, Gail P.

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N2 - OBJECTIVE - Inflammatory markers are associated with vascular disease; however, variation in the acute phase response (APR) has not been evaluated. We evaluated whether the APR magnitude in men with severe carotid artery disease (CAAD) (>80% stenosis) differed from that of men without stenosis (<15% stenosis). METHODS AND RESULTS - White males with (n=43) and without (n=61) severe CAAD receiving clinical influenza vaccinations were recruited. Their baseline and 24-hour after -vaccination blood samples were assayed for C-reactive protein (CRP), IL-6, and serum amyloid-a (SAA). In vivo APR to vaccination was measurable and varied among subjects. Adjusted for age, smoking, oral hypoglycemics, aspirin, and stain use, the relative 24-hour changes in levels of ln(CRP), ln(IL-6), and ln(SAA) were higher in men with CAAD than in men without, but only the SAA response was significant (P=0.02); the relative SAA response was 1.6 (95% confidence interval, 1.1 to 2.5) times higher in men with than without CAAD. The APR for all markers appeared to be independent of baseline levels. CONCLUSIONS - Influenza vaccination results in a mild, but measurable, APR in men with and without CAAD. SAA APR variability may be a predictor of severe vascular disease that is independent of basal SAA level.

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