TY - JOUR
T1 - Inflammatory response after influenza vaccination in men with and without carotid artery disease
AU - Carty, Cara L.
AU - Heagerty, Patrick
AU - Nakayama, Karen
AU - McClung, E. Clair
AU - Lewis, Julieann
AU - Lum, Dawn
AU - Boespflug, Erin
AU - McCloud-Gehring, Carrie
AU - Soleimani, Behrooz R.
AU - Ranchalis, Jane
AU - Bacus, Tamara J.
AU - Furlong, Clement E.
AU - Jarvik, Gail P.
PY - 2006/12
Y1 - 2006/12
N2 - OBJECTIVE - Inflammatory markers are associated with vascular disease; however, variation in the acute phase response (APR) has not been evaluated. We evaluated whether the APR magnitude in men with severe carotid artery disease (CAAD) (>80% stenosis) differed from that of men without stenosis (<15% stenosis). METHODS AND RESULTS - White males with (n=43) and without (n=61) severe CAAD receiving clinical influenza vaccinations were recruited. Their baseline and 24-hour after -vaccination blood samples were assayed for C-reactive protein (CRP), IL-6, and serum amyloid-a (SAA). In vivo APR to vaccination was measurable and varied among subjects. Adjusted for age, smoking, oral hypoglycemics, aspirin, and stain use, the relative 24-hour changes in levels of ln(CRP), ln(IL-6), and ln(SAA) were higher in men with CAAD than in men without, but only the SAA response was significant (P=0.02); the relative SAA response was 1.6 (95% confidence interval, 1.1 to 2.5) times higher in men with than without CAAD. The APR for all markers appeared to be independent of baseline levels. CONCLUSIONS - Influenza vaccination results in a mild, but measurable, APR in men with and without CAAD. SAA APR variability may be a predictor of severe vascular disease that is independent of basal SAA level.
AB - OBJECTIVE - Inflammatory markers are associated with vascular disease; however, variation in the acute phase response (APR) has not been evaluated. We evaluated whether the APR magnitude in men with severe carotid artery disease (CAAD) (>80% stenosis) differed from that of men without stenosis (<15% stenosis). METHODS AND RESULTS - White males with (n=43) and without (n=61) severe CAAD receiving clinical influenza vaccinations were recruited. Their baseline and 24-hour after -vaccination blood samples were assayed for C-reactive protein (CRP), IL-6, and serum amyloid-a (SAA). In vivo APR to vaccination was measurable and varied among subjects. Adjusted for age, smoking, oral hypoglycemics, aspirin, and stain use, the relative 24-hour changes in levels of ln(CRP), ln(IL-6), and ln(SAA) were higher in men with CAAD than in men without, but only the SAA response was significant (P=0.02); the relative SAA response was 1.6 (95% confidence interval, 1.1 to 2.5) times higher in men with than without CAAD. The APR for all markers appeared to be independent of baseline levels. CONCLUSIONS - Influenza vaccination results in a mild, but measurable, APR in men with and without CAAD. SAA APR variability may be a predictor of severe vascular disease that is independent of basal SAA level.
KW - Acute phase response
KW - Carotid artery disease
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=33751176257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751176257&partnerID=8YFLogxK
U2 - 10.1161/01.ATV.0000248534.30057.b5
DO - 10.1161/01.ATV.0000248534.30057.b5
M3 - Article
C2 - 17023683
AN - SCOPUS:33751176257
SN - 1079-5642
VL - 26
SP - 2738
EP - 2744
JO - Arteriosclerosis, thrombosis, and vascular biology
JF - Arteriosclerosis, thrombosis, and vascular biology
IS - 12
ER -