Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes

Roleofhoming receptors and other adhesion molecules

Mark A. Jutila, Ellen L. Berg, Takashi K. Kishimoto, Louis Picker, Robert F. Bargatze, Dennis K. Bishop, Charles G. Orosz, Nora W. Wu, Eugene C. Butcher

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Adhesion to the vascular endothelium precedes or is a necessary prelude to leukocyte migration into the underlying tissue. Constitutive lymphocyte trafficking through lymphoid organs is controlled by tissue-specific interactions between molecules expressed on the surface of the lymphocyte (homing receptors) and ligands (vascular addressins) expressed on endothelial cells (HEV) within lymphoid tissues. Preliminary evidence suggests that lymphocytes may employ related but distinct interactions in their entry into some chronic sites of inflammation. Other leukocytes, such as neutrophils and monocytes, express molecules related or identical to lymphocyte homing receptors, and these molecules are exquisitely regulated by chemotactic factors and appear to be involved in the homing of these cells to inflamed tissues. In addition, inflammation in vivo induces increased endothelial cell adhesiveness for leukocytes that undoubtedly plays a key role in regulating leukocyte extravasation. Tissue- and inflammation-specific leukocyte/ endothelial cell adhesion molecules constitute attractive targets for suppression or manipulation of the early stages of tissue inflammation.

Original languageEnglish (US)
Pages (from-to)727-731
Number of pages5
JournalTransplantation
Volume48
Issue number5
StatePublished - 1989

Fingerprint

Cell Adhesion
Monocytes
Neutrophils
Leukocytes
Endothelial Cells
Lymphocytes
Inflammation
Lymphocyte Homing Receptors
Adhesiveness
Chemotactic Factors
Vascular Endothelium
Cell Adhesion Molecules
Lymphoid Tissue
adhesion receptor
Ligands

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Jutila, M. A., Berg, E. L., Kishimoto, T. K., Picker, L., Bargatze, R. F., Bishop, D. K., ... Butcher, E. C. (1989). Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes: Roleofhoming receptors and other adhesion molecules. Transplantation, 48(5), 727-731.

Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes : Roleofhoming receptors and other adhesion molecules. / Jutila, Mark A.; Berg, Ellen L.; Kishimoto, Takashi K.; Picker, Louis; Bargatze, Robert F.; Bishop, Dennis K.; Orosz, Charles G.; Wu, Nora W.; Butcher, Eugene C.

In: Transplantation, Vol. 48, No. 5, 1989, p. 727-731.

Research output: Contribution to journalArticle

Jutila, MA, Berg, EL, Kishimoto, TK, Picker, L, Bargatze, RF, Bishop, DK, Orosz, CG, Wu, NW & Butcher, EC 1989, 'Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes: Roleofhoming receptors and other adhesion molecules', Transplantation, vol. 48, no. 5, pp. 727-731.
Jutila, Mark A. ; Berg, Ellen L. ; Kishimoto, Takashi K. ; Picker, Louis ; Bargatze, Robert F. ; Bishop, Dennis K. ; Orosz, Charles G. ; Wu, Nora W. ; Butcher, Eugene C. / Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes : Roleofhoming receptors and other adhesion molecules. In: Transplantation. 1989 ; Vol. 48, No. 5. pp. 727-731.
@article{16b65472777a4ac4ac4af7bfef3e8267,
title = "Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes: Roleofhoming receptors and other adhesion molecules",
abstract = "Adhesion to the vascular endothelium precedes or is a necessary prelude to leukocyte migration into the underlying tissue. Constitutive lymphocyte trafficking through lymphoid organs is controlled by tissue-specific interactions between molecules expressed on the surface of the lymphocyte (homing receptors) and ligands (vascular addressins) expressed on endothelial cells (HEV) within lymphoid tissues. Preliminary evidence suggests that lymphocytes may employ related but distinct interactions in their entry into some chronic sites of inflammation. Other leukocytes, such as neutrophils and monocytes, express molecules related or identical to lymphocyte homing receptors, and these molecules are exquisitely regulated by chemotactic factors and appear to be involved in the homing of these cells to inflamed tissues. In addition, inflammation in vivo induces increased endothelial cell adhesiveness for leukocytes that undoubtedly plays a key role in regulating leukocyte extravasation. Tissue- and inflammation-specific leukocyte/ endothelial cell adhesion molecules constitute attractive targets for suppression or manipulation of the early stages of tissue inflammation.",
author = "Jutila, {Mark A.} and Berg, {Ellen L.} and Kishimoto, {Takashi K.} and Louis Picker and Bargatze, {Robert F.} and Bishop, {Dennis K.} and Orosz, {Charles G.} and Wu, {Nora W.} and Butcher, {Eugene C.}",
year = "1989",
language = "English (US)",
volume = "48",
pages = "727--731",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes

T2 - Roleofhoming receptors and other adhesion molecules

AU - Jutila, Mark A.

AU - Berg, Ellen L.

AU - Kishimoto, Takashi K.

AU - Picker, Louis

AU - Bargatze, Robert F.

AU - Bishop, Dennis K.

AU - Orosz, Charles G.

AU - Wu, Nora W.

AU - Butcher, Eugene C.

PY - 1989

Y1 - 1989

N2 - Adhesion to the vascular endothelium precedes or is a necessary prelude to leukocyte migration into the underlying tissue. Constitutive lymphocyte trafficking through lymphoid organs is controlled by tissue-specific interactions between molecules expressed on the surface of the lymphocyte (homing receptors) and ligands (vascular addressins) expressed on endothelial cells (HEV) within lymphoid tissues. Preliminary evidence suggests that lymphocytes may employ related but distinct interactions in their entry into some chronic sites of inflammation. Other leukocytes, such as neutrophils and monocytes, express molecules related or identical to lymphocyte homing receptors, and these molecules are exquisitely regulated by chemotactic factors and appear to be involved in the homing of these cells to inflamed tissues. In addition, inflammation in vivo induces increased endothelial cell adhesiveness for leukocytes that undoubtedly plays a key role in regulating leukocyte extravasation. Tissue- and inflammation-specific leukocyte/ endothelial cell adhesion molecules constitute attractive targets for suppression or manipulation of the early stages of tissue inflammation.

AB - Adhesion to the vascular endothelium precedes or is a necessary prelude to leukocyte migration into the underlying tissue. Constitutive lymphocyte trafficking through lymphoid organs is controlled by tissue-specific interactions between molecules expressed on the surface of the lymphocyte (homing receptors) and ligands (vascular addressins) expressed on endothelial cells (HEV) within lymphoid tissues. Preliminary evidence suggests that lymphocytes may employ related but distinct interactions in their entry into some chronic sites of inflammation. Other leukocytes, such as neutrophils and monocytes, express molecules related or identical to lymphocyte homing receptors, and these molecules are exquisitely regulated by chemotactic factors and appear to be involved in the homing of these cells to inflamed tissues. In addition, inflammation in vivo induces increased endothelial cell adhesiveness for leukocytes that undoubtedly plays a key role in regulating leukocyte extravasation. Tissue- and inflammation-specific leukocyte/ endothelial cell adhesion molecules constitute attractive targets for suppression or manipulation of the early stages of tissue inflammation.

UR - http://www.scopus.com/inward/record.url?scp=0024365851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024365851&partnerID=8YFLogxK

M3 - Article

VL - 48

SP - 727

EP - 731

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 5

ER -