Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes: Roleofhoming receptors and other adhesion molecules

Mark A. Jutila, Ellen L. Berg, Takashi K. Kishimoto, Louis J. Picker, Robert F. Bargatze, Dennis K. Bishop, Charles G. Orosz, Nora W. Wu, Eugene C. Butcher

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Adhesion to the vascular endothelium precedes or is a necessary prelude to leukocyte migration into the underlying tissue. Constitutive lymphocyte trafficking through lymphoid organs is controlled by tissue-specific interactions between molecules expressed on the surface of the lymphocyte (homing receptors) and ligands (vascular addressins) expressed on endothelial cells (HEV) within lymphoid tissues. Preliminary evidence suggests that lymphocytes may employ related but distinct interactions in their entry into some chronic sites of inflammation. Other leukocytes, such as neutrophils and monocytes, express molecules related or identical to lymphocyte homing receptors, and these molecules are exquisitely regulated by chemotactic factors and appear to be involved in the homing of these cells to inflamed tissues. In addition, inflammation in vivo induces increased endothelial cell adhesiveness for leukocytes that undoubtedly plays a key role in regulating leukocyte extravasation. Tissue- and inflammation-specific leukocyte/ endothelial cell adhesion molecules constitute attractive targets for suppression or manipulation of the early stages of tissue inflammation.

Original languageEnglish (US)
Pages (from-to)727-731
Number of pages5
JournalTransplantation
Volume48
Issue number5
DOIs
StatePublished - Nov 1989

    Fingerprint

ASJC Scopus subject areas

  • Transplantation

Cite this

Jutila, M. A., Berg, E. L., Kishimoto, T. K., Picker, L. J., Bargatze, R. F., Bishop, D. K., Orosz, C. G., Wu, N. W., & Butcher, E. C. (1989). Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes: Roleofhoming receptors and other adhesion molecules. Transplantation, 48(5), 727-731. https://doi.org/10.1097/00007890-198911000-00001