Inflammation biomarkers and near-term death in older men

Nancy Swords Jenny, Norbert Yanez, Bruce M. Psaty, Lewis H. Kuller, Calvin H. Hirsch, Russell P. Tracy

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Associations of C-reactive protein (CRP) and fibrinogen with death may weaken over time. Combining both markers may improve prediction of death in older adults. In 5,828 Cardiovascular Health Study participants (United States, 1989-2000), 383 deaths (183 cardiovascular disease (CVD)) in years 1-3 (early) and 914 deaths (396 CVD) in years 4-8 (late) occurred. For men, when comparing highest to lowest quartiles, hazard ratios for early death were 4.1 (95% confidence interval (CI): 2.7, 6.3) for CRP and 4.1 (95% CI: 2.7, 6.4) for fibrinogen in models adjusted for CVD risk. For early CVD death, hazard ratios were 4.3 (95% CI: 2.2, 8.4) and 3.4 (95% CI: 1.8, 6.3), respectively. When comparing men in the highest quartiles of both biomarkers with those in the lowest, hazard ratios were 9.6 (95% CI: 4.3, 21.1) for early death and 13.5 (95% CI: 3.2, 56.5) for early CVD death. Associations were weaker for late deaths. For women, CRP (hazard ratio = 2.3, 95% CI: 1.4, 3.9), but not fibrinogen (hazard ratio = 1.3, 95% CI: 0.8, 2.2), was associated with early death. Results were similar for CVD death. Neither was associated with late deaths. CRP and fibrinogen were more strongly associated with death in older men than women and more strongly associated with early than late death. Combining both markers may identify older men at greatest risk of near-term death.

Original languageEnglish (US)
Pages (from-to)684-695
Number of pages12
JournalAmerican Journal of Epidemiology
Volume165
Issue number6
DOIs
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Biomarkers
Inflammation
Confidence Intervals
Cardiovascular Diseases
C-Reactive Protein
Fibrinogen

Keywords

  • Aged
  • C-reactive protein
  • Cardiovascular diseases
  • Death
  • Fibrinogen

ASJC Scopus subject areas

  • Epidemiology

Cite this

Jenny, N. S., Yanez, N., Psaty, B. M., Kuller, L. H., Hirsch, C. H., & Tracy, R. P. (2007). Inflammation biomarkers and near-term death in older men. American Journal of Epidemiology, 165(6), 684-695. https://doi.org/10.1093/aje/kwk057

Inflammation biomarkers and near-term death in older men. / Jenny, Nancy Swords; Yanez, Norbert; Psaty, Bruce M.; Kuller, Lewis H.; Hirsch, Calvin H.; Tracy, Russell P.

In: American Journal of Epidemiology, Vol. 165, No. 6, 03.2007, p. 684-695.

Research output: Contribution to journalArticle

Jenny, NS, Yanez, N, Psaty, BM, Kuller, LH, Hirsch, CH & Tracy, RP 2007, 'Inflammation biomarkers and near-term death in older men', American Journal of Epidemiology, vol. 165, no. 6, pp. 684-695. https://doi.org/10.1093/aje/kwk057
Jenny, Nancy Swords ; Yanez, Norbert ; Psaty, Bruce M. ; Kuller, Lewis H. ; Hirsch, Calvin H. ; Tracy, Russell P. / Inflammation biomarkers and near-term death in older men. In: American Journal of Epidemiology. 2007 ; Vol. 165, No. 6. pp. 684-695.
@article{919958c05bf24d5fa46a1d72b9a80c6a,
title = "Inflammation biomarkers and near-term death in older men",
abstract = "Associations of C-reactive protein (CRP) and fibrinogen with death may weaken over time. Combining both markers may improve prediction of death in older adults. In 5,828 Cardiovascular Health Study participants (United States, 1989-2000), 383 deaths (183 cardiovascular disease (CVD)) in years 1-3 (early) and 914 deaths (396 CVD) in years 4-8 (late) occurred. For men, when comparing highest to lowest quartiles, hazard ratios for early death were 4.1 (95{\%} confidence interval (CI): 2.7, 6.3) for CRP and 4.1 (95{\%} CI: 2.7, 6.4) for fibrinogen in models adjusted for CVD risk. For early CVD death, hazard ratios were 4.3 (95{\%} CI: 2.2, 8.4) and 3.4 (95{\%} CI: 1.8, 6.3), respectively. When comparing men in the highest quartiles of both biomarkers with those in the lowest, hazard ratios were 9.6 (95{\%} CI: 4.3, 21.1) for early death and 13.5 (95{\%} CI: 3.2, 56.5) for early CVD death. Associations were weaker for late deaths. For women, CRP (hazard ratio = 2.3, 95{\%} CI: 1.4, 3.9), but not fibrinogen (hazard ratio = 1.3, 95{\%} CI: 0.8, 2.2), was associated with early death. Results were similar for CVD death. Neither was associated with late deaths. CRP and fibrinogen were more strongly associated with death in older men than women and more strongly associated with early than late death. Combining both markers may identify older men at greatest risk of near-term death.",
keywords = "Aged, C-reactive protein, Cardiovascular diseases, Death, Fibrinogen",
author = "Jenny, {Nancy Swords} and Norbert Yanez and Psaty, {Bruce M.} and Kuller, {Lewis H.} and Hirsch, {Calvin H.} and Tracy, {Russell P.}",
year = "2007",
month = "3",
doi = "10.1093/aje/kwk057",
language = "English (US)",
volume = "165",
pages = "684--695",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Inflammation biomarkers and near-term death in older men

AU - Jenny, Nancy Swords

AU - Yanez, Norbert

AU - Psaty, Bruce M.

AU - Kuller, Lewis H.

AU - Hirsch, Calvin H.

AU - Tracy, Russell P.

PY - 2007/3

Y1 - 2007/3

N2 - Associations of C-reactive protein (CRP) and fibrinogen with death may weaken over time. Combining both markers may improve prediction of death in older adults. In 5,828 Cardiovascular Health Study participants (United States, 1989-2000), 383 deaths (183 cardiovascular disease (CVD)) in years 1-3 (early) and 914 deaths (396 CVD) in years 4-8 (late) occurred. For men, when comparing highest to lowest quartiles, hazard ratios for early death were 4.1 (95% confidence interval (CI): 2.7, 6.3) for CRP and 4.1 (95% CI: 2.7, 6.4) for fibrinogen in models adjusted for CVD risk. For early CVD death, hazard ratios were 4.3 (95% CI: 2.2, 8.4) and 3.4 (95% CI: 1.8, 6.3), respectively. When comparing men in the highest quartiles of both biomarkers with those in the lowest, hazard ratios were 9.6 (95% CI: 4.3, 21.1) for early death and 13.5 (95% CI: 3.2, 56.5) for early CVD death. Associations were weaker for late deaths. For women, CRP (hazard ratio = 2.3, 95% CI: 1.4, 3.9), but not fibrinogen (hazard ratio = 1.3, 95% CI: 0.8, 2.2), was associated with early death. Results were similar for CVD death. Neither was associated with late deaths. CRP and fibrinogen were more strongly associated with death in older men than women and more strongly associated with early than late death. Combining both markers may identify older men at greatest risk of near-term death.

AB - Associations of C-reactive protein (CRP) and fibrinogen with death may weaken over time. Combining both markers may improve prediction of death in older adults. In 5,828 Cardiovascular Health Study participants (United States, 1989-2000), 383 deaths (183 cardiovascular disease (CVD)) in years 1-3 (early) and 914 deaths (396 CVD) in years 4-8 (late) occurred. For men, when comparing highest to lowest quartiles, hazard ratios for early death were 4.1 (95% confidence interval (CI): 2.7, 6.3) for CRP and 4.1 (95% CI: 2.7, 6.4) for fibrinogen in models adjusted for CVD risk. For early CVD death, hazard ratios were 4.3 (95% CI: 2.2, 8.4) and 3.4 (95% CI: 1.8, 6.3), respectively. When comparing men in the highest quartiles of both biomarkers with those in the lowest, hazard ratios were 9.6 (95% CI: 4.3, 21.1) for early death and 13.5 (95% CI: 3.2, 56.5) for early CVD death. Associations were weaker for late deaths. For women, CRP (hazard ratio = 2.3, 95% CI: 1.4, 3.9), but not fibrinogen (hazard ratio = 1.3, 95% CI: 0.8, 2.2), was associated with early death. Results were similar for CVD death. Neither was associated with late deaths. CRP and fibrinogen were more strongly associated with death in older men than women and more strongly associated with early than late death. Combining both markers may identify older men at greatest risk of near-term death.

KW - Aged

KW - C-reactive protein

KW - Cardiovascular diseases

KW - Death

KW - Fibrinogen

UR - http://www.scopus.com/inward/record.url?scp=33847413251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847413251&partnerID=8YFLogxK

U2 - 10.1093/aje/kwk057

DO - 10.1093/aje/kwk057

M3 - Article

C2 - 17215383

AN - SCOPUS:33847413251

VL - 165

SP - 684

EP - 695

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 6

ER -