Inflammation and cancer

Lisa M. Coussens, Zena Werb

Research output: Contribution to journalReview article

8823 Scopus citations

Abstract

Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.

Original languageEnglish (US)
Pages (from-to)860-867
Number of pages8
JournalNature
Volume420
Issue number6917
DOIs
StatePublished - Dec 26 2002

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ASJC Scopus subject areas

  • General

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