Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster

David Morton, Rachel Clemens-Grisham, Dennis J. Hazelett, Anke Vermehren-Schmaedick

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Pde1c is a calcium/calmodulin-regulated, dual-specificity cyclic nucleotide phosphodiesterase. We have used a transposon insertion line to investigate the physiological function of Pde1c in Drosophila melanogaster and to show that the insertion leads to male sterility and male mating behavior defects that include reduced copulation rates. Sterility appears to be primarily due to elimination of sperm from the female reproductive system. The male mating behavior defects were fully rescued by expression of exogenous Pde1c under the control of either a Pde1c or a pan-neuronal promoter, whereas the sterility could be only partially rescued by expression of exogenous Pde1c under the control of these promoters. We also show that Pde1c has a male-specific expression pattern in the CNS with an increased number of Pde1c-expressing neurons in the abdominal ganglion in males.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalGenetics
Volume186
Issue number1
DOIs
StatePublished - Sep 2010

Fingerprint

Male Infertility
Drosophila melanogaster
Infertility
Copulation
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Calmodulin
Ganglia
Spermatozoa
Calcium
Neurons

ASJC Scopus subject areas

  • Genetics

Cite this

Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster. / Morton, David; Clemens-Grisham, Rachel; Hazelett, Dennis J.; Vermehren-Schmaedick, Anke.

In: Genetics, Vol. 186, No. 1, 09.2010, p. 159-165.

Research output: Contribution to journalArticle

Morton, D, Clemens-Grisham, R, Hazelett, DJ & Vermehren-Schmaedick, A 2010, 'Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster', Genetics, vol. 186, no. 1, pp. 159-165. https://doi.org/10.1534/genetics.110.118018
Morton, David ; Clemens-Grisham, Rachel ; Hazelett, Dennis J. ; Vermehren-Schmaedick, Anke. / Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster. In: Genetics. 2010 ; Vol. 186, No. 1. pp. 159-165.
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