Infectious complications

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Infections are the most frequently occurring complications of hematopoietic stem cell transplantation (HSCT). Myelosuppressive medications, the conditioning regimen (chemotherapy, radiation therapy), mucosal damage, type of transplant, immune-suppressive therapy, and graft-versus-host disease (GvHD) all predispose the HSCT patient to life-threatening infections. Abnormal B- and T-lymphocyte function results in impaired cellular and humoral immune function. Infections that can occur in the setting of impaired cellular immunity include fungal, protozoal, and viral diseases. Humoral defects can predispose a patient to infection with pyogenic organisms and other bacteria as well as viral infections. Patients are also often hypogammaglobulinemic following transplant. Neutrophil function is impaired by the use of corticosteroids and other medications. Functional asplenia is common. The occurrence of infections in an individual patient varies due to underlying disease and immunosuppression, endogenous host flora, and pretreatment infections. Infections also vary according to the phase of the transplant process.

Original languageEnglish (US)
Title of host publicationBlood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care
PublisherSpringer New York
Pages143-165
Number of pages23
ISBN (Print)9781441975058
DOIs
StatePublished - 2011

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Infection
Hematopoietic Stem Cell Transplantation
Virus Diseases
Transplants
Mycoses
Graft vs Host Disease
Cellular Immunity
Immunosuppression
Adrenal Cortex Hormones
Neutrophils
Radiotherapy
Bacteria
T-Lymphocytes
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Strasfeld, L. (2011). Infectious complications. In Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care (pp. 143-165). Springer New York. https://doi.org/10.1007/978-1-4419-7506-5_14

Infectious complications. / Strasfeld, Lynne.

Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. Springer New York, 2011. p. 143-165.

Research output: Chapter in Book/Report/Conference proceedingChapter

Strasfeld, L 2011, Infectious complications. in Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. Springer New York, pp. 143-165. https://doi.org/10.1007/978-1-4419-7506-5_14
Strasfeld L. Infectious complications. In Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. Springer New York. 2011. p. 143-165 https://doi.org/10.1007/978-1-4419-7506-5_14
Strasfeld, Lynne. / Infectious complications. Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. Springer New York, 2011. pp. 143-165
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