Infections and Biologic Therapy in Rheumatoid Arthritis. Our Changing Understanding of Risk and Prevention.

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20 Citations (Scopus)

Abstract

Patients with rheumatoid arthritis are at higher risk for serious infections and death from infection than the general public. Prednisone and biologic agents increase this risk, although the risk associated with biologics can be mitigated when such agents act as prednisone-sparing therapies. Some of the important causes of infectious morbidity in this setting are preventable with screening (eg, tuberculosis) or vaccination (eg, herpes zoster).

Original languageEnglish (US)
Pages (from-to)727-745
Number of pages19
JournalRheumatic Disease Clinics of North America
Volume38
Issue number4
DOIs
StatePublished - Nov 2012

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Biological Therapy
Rheumatoid Arthritis
Prednisone
Infection
Herpes Zoster
Biological Factors
Biological Products
Vaccination
Tuberculosis
Morbidity
Therapeutics

Keywords

  • Biologic therapy
  • Infection prevention
  • Infection risk
  • Infections
  • Rheumatoid arthritis
  • Screening

ASJC Scopus subject areas

  • Rheumatology

Cite this

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abstract = "Patients with rheumatoid arthritis are at higher risk for serious infections and death from infection than the general public. Prednisone and biologic agents increase this risk, although the risk associated with biologics can be mitigated when such agents act as prednisone-sparing therapies. Some of the important causes of infectious morbidity in this setting are preventable with screening (eg, tuberculosis) or vaccination (eg, herpes zoster).",
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