Infection with different HIV subtypes is associated with CD4 activation-associated dysfunction and apoptosis

Stephanie Bousheri, Candace Burke, Isaac Ssewanyana, Richard Harrigan, Jeffrey Martin, Peter Hunt, David R. Bangsberg, Huyen Cao

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Determination of HIV-1 subtype may be important in the management of HIV-infected individuals, particularly with regard to deciding the CD4 cell count at which to initiate antiretroviral therapy. Non-B subtypes, A and D, are prevalent in Uganda, and individuals infected with subtype D seem to have faster disease progression compared with those infected with subtype A. We examined the level of apoptosis in CD4 T cells in a study cohort of volunteers infected with subtypes A and D infection. Although the levels of apoptosis in the activated CD4 cells significantly decreased with viral suppression, CD4 apoptosis in individuals infected with subtype D were found to be significantly higher compared with those infected with subtype A before antiretroviral treatment. Surface expression of PD-1 on CD4 cells in subtype D was substantially higher compared with that in subtype A (P = 0.03). This difference was not observed in the CD8 population (P > 0.05). Our findings suggest that the infecting HIV subtypes exert an independent influence on the disease outcome in response to antiretroviral treatment.

Original languageEnglish (US)
Pages (from-to)548-552
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes
Volume52
Issue number5
DOIs
StatePublished - Dec 1 2009

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ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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