TY - JOUR
T1 - Infection of the Retina by Human Immunodeficiency Virus Type I
AU - Pomerantz, Roger J.
AU - Kuritzkes, Daniel R.
AU - de la Monte, Suzanne M.
AU - Rota, Teresa R.
AU - Baker, Ann S.
AU - Albert, Daniel
AU - Bor, David H.
AU - Feldman, Edward L.
AU - Schooley, Robert T.
AU - Hirsch, Martin S.
PY - 1987/12/24
Y1 - 1987/12/24
N2 - HUMAN immunodeficiency virus (HIV) is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).1 2 3 4 HIV penetrates specific cells bearing the CD4 surface antigen5,6 and has been observed in helper T lymphocytes, monocytes, Langerhans' cells, and recently, astrocytes, endothelial cells, oligodendrocytes, and neurons.7 8 9 10 11 HIV-infected cells have been found in the blood, semen, vaginal secretions, breast milk, lymph nodes, brain, spinal cord, and peripheral nerves.7 8 9 10 11 12 13 14 15 16 17 18 19 Many patients with HIV infection have a variety of ocular abnormalities not associated with obvious opportunistic infections; these abnormalities include cotton-wool spots and microvascular changes of the retina.20 21 22 23 24 25 26 27 These observations, together with the established neurotropism of HIV,.
AB - HUMAN immunodeficiency virus (HIV) is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).1 2 3 4 HIV penetrates specific cells bearing the CD4 surface antigen5,6 and has been observed in helper T lymphocytes, monocytes, Langerhans' cells, and recently, astrocytes, endothelial cells, oligodendrocytes, and neurons.7 8 9 10 11 HIV-infected cells have been found in the blood, semen, vaginal secretions, breast milk, lymph nodes, brain, spinal cord, and peripheral nerves.7 8 9 10 11 12 13 14 15 16 17 18 19 Many patients with HIV infection have a variety of ocular abnormalities not associated with obvious opportunistic infections; these abnormalities include cotton-wool spots and microvascular changes of the retina.20 21 22 23 24 25 26 27 These observations, together with the established neurotropism of HIV,.
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U2 - 10.1056/NEJM198712243172607
DO - 10.1056/NEJM198712243172607
M3 - Article
C2 - 3479685
AN - SCOPUS:0023472072
SN - 0028-4793
VL - 317
SP - 1643
EP - 1647
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 26
ER -