Infection of the Retina by Human Immunodeficiency Virus Type I

Roger J. Pomerantz, Daniel R. Kuritzkes, Suzanne M. de la Monte, Teresa R. Rota, Ann S. Baker, Daniel Albert, David H. Bor, Edward L. Feldman, Robert T. Schooley, Martin S. Hirsch

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Abstract

HUMAN immunodeficiency virus (HIV) is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).1 2 3 4 HIV penetrates specific cells bearing the CD4 surface antigen5,6 and has been observed in helper T lymphocytes, monocytes, Langerhans' cells, and recently, astrocytes, endothelial cells, oligodendrocytes, and neurons.7 8 9 10 11 HIV-infected cells have been found in the blood, semen, vaginal secretions, breast milk, lymph nodes, brain, spinal cord, and peripheral nerves.7 8 9 10 11 12 13 14 15 16 17 18 19 Many patients with HIV infection have a variety of ocular abnormalities not associated with obvious opportunistic infections; these abnormalities include cotton-wool spots and microvascular changes of the retina.20 21 22 23 24 25 26 27 These observations, together with the established neurotropism of HIV,.

Original languageEnglish (US)
Pages (from-to)1643-1647
Number of pages5
JournalNew England Journal of Medicine
Volume317
Issue number26
DOIs
StatePublished - Dec 24 1987

ASJC Scopus subject areas

  • Medicine(all)

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    Pomerantz, R. J., Kuritzkes, D. R., de la Monte, S. M., Rota, T. R., Baker, A. S., Albert, D., Bor, D. H., Feldman, E. L., Schooley, R. T., & Hirsch, M. S. (1987). Infection of the Retina by Human Immunodeficiency Virus Type I. New England Journal of Medicine, 317(26), 1643-1647. https://doi.org/10.1056/NEJM198712243172607