Infected aortic aneurysm caused by Helicobacter cinaedi: case series and systematic review of the literature

Takahiro Matsuo, Nobuyoshi Mori, Atsushi Mizuno, Aki Sakurai, Fujimi Kawai, Jay Starkey, Daisuke Ohkushi, Kohei Abe, Manabu Yamasaki, Joji Ito, Kunihiko Yoshino, Yumiko Mikami, Yuki Uehara, Keiichi Furukawa

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Helicobacter cinaedi is rarely identified as a cause of infected aneurysms; however, the number of reported cases has been increasing over several decades, especially in Japan. We report three cases of aortic aneurysm infected by H. cinaedi that were successfully treated using meropenem plus surgical stent graft replacement or intravascular stenting. Furthermore, we performed a systematic review of the literature regarding aortic aneurysm infected by H. cinaedi. Case presentation: We present three rare cases of infected aneurysm caused by H. cinaedi in adults. Blood and tissue cultures and 16S rRNA gene sequencing were used for diagnosis. Two patients underwent urgent surgical stent graft replacement, and the other patient underwent intravascular stenting. All three cases were treated successfully with intravenous meropenem for 4 to 6 weeks. Conclusions: These cases suggest that although aneurysms infected by H. cinaedi are rare, clinicians should be aware of H. cinaedi as a potential causative pathogen, even in immunocompetent patients. Prolonged incubation periods for blood cultures are necessary for the accurate detection of H. cinaedi.

Original languageEnglish (US)
Article number854
JournalBMC Infectious Diseases
Volume20
Issue number1
DOIs
StatePublished - Dec 2020

Keywords

  • Case report
  • Helicobacter cinaedi
  • Infected aneurysm
  • Japan

ASJC Scopus subject areas

  • Infectious Diseases

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