Induction of Salmonella stress proteins upon infection of macrophages

Nancy A. Buchmeier, Fred Heffron

    Research output: Contribution to journalArticle

    307 Scopus citations

    Abstract

    Regulated expression of bacterial genes allows a pathogen to adapt to new environmental conditions within the host. The synthesis of over 30 Salmonella proteins is selectively induced during infection of macrophages. Two proteins induced by Salmonella are the heat shock proteins GroEL and DnaK. Two avirulent, macrophage-sensitive mutants of Salmonella synthesize GroEL and DnaK but fail to synthesize different subsets of proteins normally induced within the macrophage. Enhanced expression of selected Salmonella proteins contributes to bacterial survival within macrophages and may also contribute to the apparent immunodominance of heat shock proteins.

    Original languageEnglish (US)
    Pages (from-to)730-732
    Number of pages3
    JournalScience
    Volume248
    Issue number4956
    DOIs
    StatePublished - Jan 1 1990

    ASJC Scopus subject areas

    • General

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