Induction of “luteinization” in cultures of granulosa cells by chorionic gonadotropins

David H. Van Thiel, William E. Bridson, Peter O. Kohler

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We have shown that porcine granulosa cells undergo morphologic and biosynthetic changes similar to luteinization when exposed to chorionic gonadotropin in tissue culture. Both a crude urinary chorionic gonadotropin and a gonadotropin produced in culture by the JEG-7 clonal line of human choriocarcinoma cells were effective. Morphologic and biosynthetic “luteinization” occurred synchronously and a minimum of 1.0 IU gonadotropin /ml medium was necessary. Induction of progesterone synthesis occurred more rapidly and was of greater magnitude with increasing concentrations of both chorionic gonadotropin preparations.

Original languageEnglish (US)
Pages (from-to)622-624
Number of pages3
Issue number2
StatePublished - Aug 1971
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology


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