Induction of “luteinization” in cultures of granulosa cells by chorionic gonadotropins

David H. Van Thiel, William E. Bridson, Peter O. Kohler

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We have shown that porcine granulosa cells undergo morphologic and biosynthetic changes similar to luteinization when exposed to chorionic gonadotropin in tissue culture. Both a crude urinary chorionic gonadotropin and a gonadotropin produced in culture by the JEG-7 clonal line of human choriocarcinoma cells were effective. Morphologic and biosynthetic “luteinization” occurred synchronously and a minimum of 1.0 IU gonadotropin /ml medium was necessary. Induction of progesterone synthesis occurred more rapidly and was of greater magnitude with increasing concentrations of both chorionic gonadotropin preparations.

Original languageEnglish (US)
Pages (from-to)622-624
Number of pages3
JournalEndocrinology
Volume89
Issue number2
DOIs
StatePublished - Aug 1971

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Induction of “luteinization” in cultures of granulosa cells by chorionic gonadotropins'. Together they form a unique fingerprint.

Cite this