Induction of “luteinization” in cultures of granulosa cells by chorionic gonadotropins

David H. Van Thiel, William E. Bridson, Peter O. Kohler

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We have shown that porcine granulosa cells undergo morphologic and biosynthetic changes similar to luteinization when exposed to chorionic gonadotropin in tissue culture. Both a crude urinary chorionic gonadotropin and a gonadotropin produced in culture by the JEG-7 clonal line of human choriocarcinoma cells were effective. Morphologic and biosynthetic “luteinization” occurred synchronously and a minimum of 1.0 IU gonadotropin /ml medium was necessary. Induction of progesterone synthesis occurred more rapidly and was of greater magnitude with increasing concentrations of both chorionic gonadotropin preparations.

Original languageEnglish (US)
Pages (from-to)622-624
Number of pages3
JournalEndocrinology
Volume89
Issue number2
DOIs
StatePublished - Aug 1971

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Induction of “luteinization” in cultures of granulosa cells by chorionic gonadotropins'. Together they form a unique fingerprint.

  • Cite this